The rapid, typically all-or-none process of mitochondrial outer membrane permeabilization (MOMP) constitutes a primary cell death decision that is controlled by the Bcl-2 family interactome. However, how strict all-or-none MOMP decisions are governed by and emanate from the dynamic interplay of pro- and antiapoptotic Bcl-2 family members remains incompletely understood. In particular, it is unclear to which extent the shuttling of Bcl-2 family species between lipid and aqueous phases contributes to regulating MOMP sensitivity. Here, we studied the interplay of tBid, Bax, and Bcl-xL, using a combined approach of deterministic mathematical modeling and retrospective as well as prospective experimental testing of model predictions. Systems mod...
AbstractBcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria d...
Bcl-2 family members form a network of protein-protein interactions that regulate apoptosis through ...
The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to...
SummaryThe Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomeri...
Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabil...
The Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomerizes and...
The proteins of the Bcl-2 family are key regulators of apoptosis. They form a complex interaction ne...
The Bcl-2 protein family controls mitochondrial outer membrane permeabilization (MOMP), a point of n...
The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the r...
Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathwa...
SummaryIn normal circumstances, the Bcl-2 family dutifully governs when cells die. However, the rule...
During apoptosis, the BCL-2 protein family controls mitochondrial outer membrane permeabilization (M...
Antiapoptotic Bcl-2 proteins on mitochondria inhibit prodeath proteins, such as Bax, which are found...
AbstractProtein–protein interactions between the Bcl2 family proteins regulate apoptosis. An imbalan...
AbstractBased on their membrane-permeabilizing activity in vitro, it has been proposed that Bax-like...
AbstractBcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria d...
Bcl-2 family members form a network of protein-protein interactions that regulate apoptosis through ...
The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to...
SummaryThe Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomeri...
Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabil...
The Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomerizes and...
The proteins of the Bcl-2 family are key regulators of apoptosis. They form a complex interaction ne...
The Bcl-2 protein family controls mitochondrial outer membrane permeabilization (MOMP), a point of n...
The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the r...
Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathwa...
SummaryIn normal circumstances, the Bcl-2 family dutifully governs when cells die. However, the rule...
During apoptosis, the BCL-2 protein family controls mitochondrial outer membrane permeabilization (M...
Antiapoptotic Bcl-2 proteins on mitochondria inhibit prodeath proteins, such as Bax, which are found...
AbstractProtein–protein interactions between the Bcl2 family proteins regulate apoptosis. An imbalan...
AbstractBased on their membrane-permeabilizing activity in vitro, it has been proposed that Bax-like...
AbstractBcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria d...
Bcl-2 family members form a network of protein-protein interactions that regulate apoptosis through ...
The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to...