Deregulation of the ubiquitin-protein ligase E6AP contributes to the development of the Angelman syndrome and to cervical carcinogenesis suggesting that the activity of E6AP needs to be under tight control. However, how E6AP activity is regulated at the post-translational level under non-pathologic conditions is poorly understood. In this study, we report that the giant protein HERC2, which is like E6AP a member of the HECT family of ubiquitin-protein ligases, binds to E6AP. The interaction is mediated by the RCC1-like domain 2 of HERC2 and a region spanning amino acid residues 150-200 of E6AP. Furthermore, we provide evidence that HERC2 stimulates the ubiquitin-protein ligase activity of E6AP in vitro and within cells and that this stimula...
Deregulation of the HECT-type ubiquitin ligase E6AP (UBE3A) is implicated in human papilloma virus-i...
HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implicated in an...
The tumor suppressor p53 is a transcription factor that coordinates the cellular response to several...
Angelman Syndrome is a severe neurological disorder caused by mutations in the UBE3A gene, which enc...
Post-translational modification of proteins by ubiquitin (''ubiquitination'') determines proteolytic...
The ubiquitin ligase E6-AP (E6-associated protein) represents a prime example for the notion that de...
Homologous to the E6AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-li...
Deregulation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been...
HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implicated in an...
E6-associated protein (E6AP) is a member of HECT domain family of E3 ubiquitin (UB) ligase that is r...
The HECT domain E3 ubiquitin ligase E6AP (UBE3A) is critical for the development of human papillomav...
ABSTRACT: HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implic...
A mutation in the HERC2 gene has been linked to a severe neurodevelopmental disorder with similariti...
A mutation in the HERC2 gene has been linked to a severe neurodevelopmental disorder with similariti...
The Estrogen Receptor alpha (ER alpha) is a multi-domain transcription factor that has been extensiv...
Deregulation of the HECT-type ubiquitin ligase E6AP (UBE3A) is implicated in human papilloma virus-i...
HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implicated in an...
The tumor suppressor p53 is a transcription factor that coordinates the cellular response to several...
Angelman Syndrome is a severe neurological disorder caused by mutations in the UBE3A gene, which enc...
Post-translational modification of proteins by ubiquitin (''ubiquitination'') determines proteolytic...
The ubiquitin ligase E6-AP (E6-associated protein) represents a prime example for the notion that de...
Homologous to the E6AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-li...
Deregulation of the ubiquitin ligase E6 associated protein (E6AP) encoded by the UBE3A gene has been...
HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implicated in an...
E6-associated protein (E6AP) is a member of HECT domain family of E3 ubiquitin (UB) ligase that is r...
The HECT domain E3 ubiquitin ligase E6AP (UBE3A) is critical for the development of human papillomav...
ABSTRACT: HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implic...
A mutation in the HERC2 gene has been linked to a severe neurodevelopmental disorder with similariti...
A mutation in the HERC2 gene has been linked to a severe neurodevelopmental disorder with similariti...
The Estrogen Receptor alpha (ER alpha) is a multi-domain transcription factor that has been extensiv...
Deregulation of the HECT-type ubiquitin ligase E6AP (UBE3A) is implicated in human papilloma virus-i...
HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implicated in an...
The tumor suppressor p53 is a transcription factor that coordinates the cellular response to several...