We have determined the crystal structure of the ligand binding fragment of the neural cell adhesion molecule axonin-1/TAG-1 comprising the first four immunoglobulin (Ig) domains. The overall structure of axonin-1Ig1 4 is U-shaped due to contacts between domains 1 and 4 and domains 2 and 3. In the crystals, these molecules are aligned in a string with adjacent molecules oriented in an anti-parallel fashion and their C termini perpendicular to the string. This arrangement suggests that cell adhesion by homophilic axonin-1 interaction occurs by the formation of a linear zipper-like array in which the axonin-1 molecules are alternately provided by the two apposed membranes. In accordance with this model, mutations in a loop critical for the for...
The development of specific connections between neurons and targets is a critical step in the making...
The latest structural studies of immunoglobulin superfamily cell adhesion molecules are driving a sh...
SummaryPolymorphic adhesion molecules neurexin and neuroligin (NL) mediate asymmetric trans-synaptic...
We have determined the crystal structure of the ligand binding fragment of the neural cell adhesion ...
AbstractWe have determined the crystal structure of the ligand binding fragment of the neural cell a...
Human TAG-1 is a neural cell adhesion molecule that is crucial for the development of the nervous sy...
AbstractThe neural cell adhesion molecule, NCAM, mediates Ca2+-independent cell-cell and cell-substr...
The neural cell adhesion molecule, NCAM, mediates Ca(2+)-independent cell-cell and cell-substratum a...
Neural cell adhesion molecules of the immunoglobulin superfamily mediate cellular interactions via h...
Neural cell adhesion molecules of the immunoglobulin superfamily mediate cellular interactions via h...
The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-ce...
AbstractThe neural cell adhesion molecule, NCAM, mediates Ca2+-independent cell-cell and cell-substr...
SummaryThe neural cell adhesion molecule L1 participates in homophilic interactions important for ax...
During neuron development, the precise wiring of neuronal network is mainly secured by molecular pro...
The neural cell adhesion molecule L1 participates in homophilic interactions important for axon guid...
The development of specific connections between neurons and targets is a critical step in the making...
The latest structural studies of immunoglobulin superfamily cell adhesion molecules are driving a sh...
SummaryPolymorphic adhesion molecules neurexin and neuroligin (NL) mediate asymmetric trans-synaptic...
We have determined the crystal structure of the ligand binding fragment of the neural cell adhesion ...
AbstractWe have determined the crystal structure of the ligand binding fragment of the neural cell a...
Human TAG-1 is a neural cell adhesion molecule that is crucial for the development of the nervous sy...
AbstractThe neural cell adhesion molecule, NCAM, mediates Ca2+-independent cell-cell and cell-substr...
The neural cell adhesion molecule, NCAM, mediates Ca(2+)-independent cell-cell and cell-substratum a...
Neural cell adhesion molecules of the immunoglobulin superfamily mediate cellular interactions via h...
Neural cell adhesion molecules of the immunoglobulin superfamily mediate cellular interactions via h...
The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-ce...
AbstractThe neural cell adhesion molecule, NCAM, mediates Ca2+-independent cell-cell and cell-substr...
SummaryThe neural cell adhesion molecule L1 participates in homophilic interactions important for ax...
During neuron development, the precise wiring of neuronal network is mainly secured by molecular pro...
The neural cell adhesion molecule L1 participates in homophilic interactions important for axon guid...
The development of specific connections between neurons and targets is a critical step in the making...
The latest structural studies of immunoglobulin superfamily cell adhesion molecules are driving a sh...
SummaryPolymorphic adhesion molecules neurexin and neuroligin (NL) mediate asymmetric trans-synaptic...