We present a rapid, reproducible and sensitive neurotoxicity testing platform that combines the benefits of neurite outgrowth analysis with cell patterning. This approach involves patterning neuronal cells within a hexagonal array to standardize the distance between neighbouring cellular nodes, and thereby standardize the length of the neurite interconnections. This feature coupled with defined assay coordinates provides a streamlined display for rapid and sensitive analysis. We have termed this the network formation assay (NFA). To demonstrate the assay we have used a novel cell patterning technique involving thin film poly(dimethylsiloxane) (PDMS) microcontact printing. Differentiated human SH-SY5Y neuroblastoma cells colonized the array ...
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard assessment. Si...
The central nervous system consists of a multitude of different neurons and supporting cells that fo...
The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a test ba...
We present a rapid, reproducible and sensitive neurotoxicity testing platform that combines the bene...
Spatially defined neuronal networks have great potential to be used in a wide spectrum of neurobiolo...
Chemicals that specifically alter human neurite outgrowth pose a hazard for the development of the n...
Chemicals that specifically inhibit human neurite outgrowth pose a hazard to the developing nervous ...
Chemicals that specifically alter human neurite outgrowth pose a hazard for the development of the n...
The developing nervous system is particularly vulnerable to chemical insults. Exposure to chemicals ...
The developing nervous system is particularly vulnerable to chemical insults. Exposure to chemicals ...
Neurite outgrowth assay: 1x105 neurons were plated into XONA-microfluidic chambers (standard neuron ...
<p>There is an increased need to develop reliable and efficient screening tools to identify chemical...
Proper brain development is based on the orchestration of key neurodevelopmental processes (KNDP), i...
Identification of chemicals that pose a hazard to the developing nervous system is the first step in...
In this study, we designed and manufactured a series of different microstructure topographical cues ...
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard assessment. Si...
The central nervous system consists of a multitude of different neurons and supporting cells that fo...
The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a test ba...
We present a rapid, reproducible and sensitive neurotoxicity testing platform that combines the bene...
Spatially defined neuronal networks have great potential to be used in a wide spectrum of neurobiolo...
Chemicals that specifically alter human neurite outgrowth pose a hazard for the development of the n...
Chemicals that specifically inhibit human neurite outgrowth pose a hazard to the developing nervous ...
Chemicals that specifically alter human neurite outgrowth pose a hazard for the development of the n...
The developing nervous system is particularly vulnerable to chemical insults. Exposure to chemicals ...
The developing nervous system is particularly vulnerable to chemical insults. Exposure to chemicals ...
Neurite outgrowth assay: 1x105 neurons were plated into XONA-microfluidic chambers (standard neuron ...
<p>There is an increased need to develop reliable and efficient screening tools to identify chemical...
Proper brain development is based on the orchestration of key neurodevelopmental processes (KNDP), i...
Identification of chemicals that pose a hazard to the developing nervous system is the first step in...
In this study, we designed and manufactured a series of different microstructure topographical cues ...
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard assessment. Si...
The central nervous system consists of a multitude of different neurons and supporting cells that fo...
The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a test ba...