The foreign lesion: DNAs with damage generated, for example, by UV light are not good targets for standard replicative DNA polymerases. A DNA polymerase has been derived by directed evolution that faithfully amplifies light-damaged DNA. Interestingly, a single mutation is sufficient for this propert
Irradiation of organisms with UV light produces genotoxic and mutagenic lesions in DNA. Replication ...
Nucleic acid polymerases are the most important reagents in biotechnology. Unfortunately, their high...
In contrast to the dnaE486 mutation, which is nearly 'dead-stop', dnaE1026 allows DNA synt...
Cells that have been irradiated with ultraviolet light (UV) suffer damage to their DNA, primarily in...
AbstractMost types of DNA damage block the passage of the replication machinery. In order to bypass ...
DNA damage is a ubiquitous challenge to replication in cells, as damage causes replicative polymeras...
Most types of DNA damage block the passage of the replication machinery. In order to bypass these bl...
The ability of yeast DNA polymerase mutant strains to carry out repair synthesis after UV irradiatio...
An essential prerequisite for all organisms is to keep its genome intact and to accurately duplicate...
This paper describes experiments intended to decide whether UV lesions in DNA act as absolute blocks...
This paper describes experiments intended to decide whether UV lesions in DNA act as absolute blocks...
DNA polymerases find broad applications in molecular biology techniques (e.g., polymerase chain reac...
DNA polymerases are the enzymes that catalyse all DNA synthesis in Nature often with astounding spee...
All cells need not only to remove damage from their DNA, but also to be able to replicate DNA contai...
DNA damage is generated continually inside cells. In order to be able to replicate past damaged base...
Irradiation of organisms with UV light produces genotoxic and mutagenic lesions in DNA. Replication ...
Nucleic acid polymerases are the most important reagents in biotechnology. Unfortunately, their high...
In contrast to the dnaE486 mutation, which is nearly 'dead-stop', dnaE1026 allows DNA synt...
Cells that have been irradiated with ultraviolet light (UV) suffer damage to their DNA, primarily in...
AbstractMost types of DNA damage block the passage of the replication machinery. In order to bypass ...
DNA damage is a ubiquitous challenge to replication in cells, as damage causes replicative polymeras...
Most types of DNA damage block the passage of the replication machinery. In order to bypass these bl...
The ability of yeast DNA polymerase mutant strains to carry out repair synthesis after UV irradiatio...
An essential prerequisite for all organisms is to keep its genome intact and to accurately duplicate...
This paper describes experiments intended to decide whether UV lesions in DNA act as absolute blocks...
This paper describes experiments intended to decide whether UV lesions in DNA act as absolute blocks...
DNA polymerases find broad applications in molecular biology techniques (e.g., polymerase chain reac...
DNA polymerases are the enzymes that catalyse all DNA synthesis in Nature often with astounding spee...
All cells need not only to remove damage from their DNA, but also to be able to replicate DNA contai...
DNA damage is generated continually inside cells. In order to be able to replicate past damaged base...
Irradiation of organisms with UV light produces genotoxic and mutagenic lesions in DNA. Replication ...
Nucleic acid polymerases are the most important reagents in biotechnology. Unfortunately, their high...
In contrast to the dnaE486 mutation, which is nearly 'dead-stop', dnaE1026 allows DNA synt...
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