Background: Limited research is available that explores major limb amputation and the World Health Organization’s International Classification of Functioning, Disability and Health (ICF). Objectives: To investigate the barriers, participation restriction and functioning levels experienced by people with a major limb amputation. Study design: Secondary data analysis. Method: Relevant data for 148 people with major limb amputation were extracted from the National Physical and Sensory Disability Database in Ireland. Results: The most common environmental barriers encountered were climate, physical environment and income. Participation restriction was most commonly experienced in sports/physical recreation, leisure/cultural activity...