Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationsh...
The antitumor and cellular pharmacological properties of the trans-Pt(IV) complex, trans-[PtCl2(OH)(...
Cisplatin analogues, cis-dichloro(ethylenediamine-N,N'-di-3-propanoic acid)platinum(II) (1) and cis-...
The antitumor activity of the stereoisomers of dichloro-1,2-bis(4-hydroxyphenyl)ethylenediamineplati...
Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corres...
The cytotoxicities of two platinum(IV) complexes of formula [PtX(2)(eddp)] - nH(2)O (eddp = ethylene...
The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)...
The cytotoxicities of two platinum(IV) complexes of formula [PtX2(eddp)].nH2O (eddp=ethylenediamine-...
Three novel complexes of platinum(II) with R(2)edda bidentate ligands [PtCl2(R(2)edda)] (R = Me, Et,...
Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)(2)eddip}] (n = 2, 4: 1, 2, respect...
Platinum(II) complexes (1-4) with bidentate N,N'-ligands, O,O'-dialkyl esters (alkyl = ethyl, n-prop...
The present study describes the synthesis and anticancer activity of novel octahedral Pt-IV complexe...
The synthesis of ethylenediamine-N,N-di-S,S-(2,2-dibenzyl)acetic acid (H-2-S,S-eddba) and its ethyl-...
Synthesis of four new platinum(IV) complexes (C1-C4) with bidentate N,N'-ligand precursors, O,O'-dia...
The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)center dot nH(2)O (S,S-e...
This paper reports on syntheses and characterization of chlorotribromo(O,O-n-butyl-ethylenediamine-N...
The antitumor and cellular pharmacological properties of the trans-Pt(IV) complex, trans-[PtCl2(OH)(...
Cisplatin analogues, cis-dichloro(ethylenediamine-N,N'-di-3-propanoic acid)platinum(II) (1) and cis-...
The antitumor activity of the stereoisomers of dichloro-1,2-bis(4-hydroxyphenyl)ethylenediamineplati...
Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corres...
The cytotoxicities of two platinum(IV) complexes of formula [PtX(2)(eddp)] - nH(2)O (eddp = ethylene...
The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)...
The cytotoxicities of two platinum(IV) complexes of formula [PtX2(eddp)].nH2O (eddp=ethylenediamine-...
Three novel complexes of platinum(II) with R(2)edda bidentate ligands [PtCl2(R(2)edda)] (R = Me, Et,...
Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)(2)eddip}] (n = 2, 4: 1, 2, respect...
Platinum(II) complexes (1-4) with bidentate N,N'-ligands, O,O'-dialkyl esters (alkyl = ethyl, n-prop...
The present study describes the synthesis and anticancer activity of novel octahedral Pt-IV complexe...
The synthesis of ethylenediamine-N,N-di-S,S-(2,2-dibenzyl)acetic acid (H-2-S,S-eddba) and its ethyl-...
Synthesis of four new platinum(IV) complexes (C1-C4) with bidentate N,N'-ligand precursors, O,O'-dia...
The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)center dot nH(2)O (S,S-e...
This paper reports on syntheses and characterization of chlorotribromo(O,O-n-butyl-ethylenediamine-N...
The antitumor and cellular pharmacological properties of the trans-Pt(IV) complex, trans-[PtCl2(OH)(...
Cisplatin analogues, cis-dichloro(ethylenediamine-N,N'-di-3-propanoic acid)platinum(II) (1) and cis-...
The antitumor activity of the stereoisomers of dichloro-1,2-bis(4-hydroxyphenyl)ethylenediamineplati...