Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort
- Aleksandrova, K.
- Jenab, M.
- Leitzmann, M.
- Bueno-de-Mesquita, B.
- Kaaks, R.
- Trichopoulou, A.
- Bamia, C.
- Lagiou, P.
- Rinaldi, S.
- Freisling, H.
- Carayol, M.
- Pischon, T.
- Drogan, D.
- Weiderpass, E.
- Jakszyn, P.
- Overvad, K.
- Dahm, C.C.
- Tjønneland, A.
- Bouton-Ruault, M.C.
- Kühn, T.
- Peppa, E.
- Valanou, E.
- La Vecchia, C.
- Palli, D.
- Panico, S.
- Sacerdote, C.
- Agnoli, C.
- Tumino, R.
- May, A.
- van Vulpen, J.
- Benjaminsen Borch, K.
- Oluwafemi Oyeyemi, S.
- Quirós, J.R.
- Bonet, C.
- Sánchez, M.J.
- Dorronsoro, M.
- Navarro, C.
- Barricarte, A.
- van Guelpen, B.
- Wennberg, P.
- Key, T.J.
- Khaw, K.T.
- Wareham, N.
- Assi, N.
- Ward, H.A.
- Aune, D.
- Riboli, E.
- Boeing, H.
DOIAbstract
Background: There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. Methods: We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equiva...
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