Enhancers regulate the expression of target genes across large genomic distances, but it is unclear how recently discovered topological domains affect this regulation. Reporting in this issue of Developmental Cell, Symmons et al. (2016) show that the endogenous Shh topological domain promotes functional interactions between Shh and its remote enhancer
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute ...
SummaryA key finding of the ENCODE project is that the enhancer landscape of mammalian cells undergo...
Enhancers are regulatory genomic elements that are responsible for adequate spatio-temporal gene-exp...
SummaryGene expression often requires interaction between promoters and distant enhancers, which occ...
Precise spatiotemporal gene expression during embryonic developmental is controlled by cis- regulato...
Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment...
The expression of a large number of genes is regulated by regulatory elements that are located far a...
Author summary During development, enhancer sequences tightly regulate the spatio-temporal expressio...
Chromosome structure in mammals is thought to regulate transcription by modulating three-dimensional...
Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m ...
The discovery of domains of preferential interaction or Topologically Associating Domains (TADs) has...
AbstractRecent studies have shown that chromosomes in a range of organisms are compartmentalized in ...
Background The spatial organization of the mammalian genome relies upon the formation of chromatin d...
Long-range gene regulation involves physical proximity between enhancers and promoters to generate p...
Regulation of gene expression is a complex process that requires the action of DNA elements such as ...
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute ...
SummaryA key finding of the ENCODE project is that the enhancer landscape of mammalian cells undergo...
Enhancers are regulatory genomic elements that are responsible for adequate spatio-temporal gene-exp...
SummaryGene expression often requires interaction between promoters and distant enhancers, which occ...
Precise spatiotemporal gene expression during embryonic developmental is controlled by cis- regulato...
Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment...
The expression of a large number of genes is regulated by regulatory elements that are located far a...
Author summary During development, enhancer sequences tightly regulate the spatio-temporal expressio...
Chromosome structure in mammals is thought to regulate transcription by modulating three-dimensional...
Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m ...
The discovery of domains of preferential interaction or Topologically Associating Domains (TADs) has...
AbstractRecent studies have shown that chromosomes in a range of organisms are compartmentalized in ...
Background The spatial organization of the mammalian genome relies upon the formation of chromatin d...
Long-range gene regulation involves physical proximity between enhancers and promoters to generate p...
Regulation of gene expression is a complex process that requires the action of DNA elements such as ...
Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute ...
SummaryA key finding of the ENCODE project is that the enhancer landscape of mammalian cells undergo...
Enhancers are regulatory genomic elements that are responsible for adequate spatio-temporal gene-exp...
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