Predicting the optimal Basal insulin infusion pattern in children and adolescents on insulin pumps

Holterhus, P.M.
Bokelmann, J.
Riepe, F.
Heidtmann, B.
Wagner, V.
Rami-Merhar, B.
Kapellen, T.
Raile, K.
Quester, W.
Holl, R.W.

Open link

Publication date

June 2013

DOI

10.2337/dc12-1705

Publisher

American Diabetes Association

Abstract

OBJECTIVE: We aimed at developing and cross-validating a mathematical prediction model for an optimal basal insulin infusion pattern for children with type 1 diabetes on continuous subcutaneous insulin infusion therapy (CSII). RESEARCH DESIGN AND METHODS: We used the German/Austrian DPV-Wiss database for quality control and scientific surveys in pediatric diabetology and retrieved all CSII patients <20 years of age (November 2009). A total of 1,248 individuals from our previous study were excluded (dataset 1), resulting in 6,063 CSII patients (dataset 2) (mean age 10.6 +/- 4.3 years). Only the most recent basal insulin infusion rates (BRs) were considered. BR patterns were identified and corresponding patients sorted by unsupervised cluster...