Risk factors for malignant ventricular arrhythmias in lamin A/C mutation carriers a European cohort study
- van Rijsingen, I.A.W.
- Arbustini, E.
- Elliott, P.M.
- Mogensen, J.
- Hermans-van Ast, J.F.
- van der Kooi, A.J.
- van Tintelen, J.P.
- van den Berg, M.P.
- Pilotto, A.
- Pasotti, M.
- Jenkins, S.
- Rowland, C.
- Aslam, U.
- Wilde, A.A.M.
- Perrot, A.
- Pankuweit, S.
- Zwinderman, A.H.
- Charron, P.
- Pinto, Y.M.
DOIAbstract
OBJECTIVES: The purpose of this study was to determine risk factors that predict malignant ventricular arrhythmias (MVA) in Lamin A/C (LMNA) mutation carriers. BACKGROUND: LMNA mutations cause a variety of clinical phenotypes, including dilated cardiomyopathy and conduction disease. Many LMNA mutation carriers have a poor prognosis, because of a high frequency of MVA and progression to end-stage heart failure. However, it is unclear how to identify mutation carriers that are at risk for MVA. METHODS: In this multicenter cohort of 269 LMNA mutation carriers, we evaluated risk factors for MVA, defined as sudden cardiac death, resuscitation, and appropriate implantable cardioverter-defibrillator (ICD) treatment. RESULTS: In a median follow-up ...
Add to ORKG