Upregulation of myocardial estrogen receptors in human aortic stenosis
- Nordmeyer, J.
- Eder, S.
- Mahmoodzadeh, S.
- Martus, P.
- Fielitz, J.
- Bass, J.
- Bethke, N.
- Zurbruegg, H.R.
- Pregla, R.
- Hetzer, R.
- Regitz-Zagrosek, V.
Publication date
November 2004
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
Estrogen receptor (ER)-mediated effects have been associated with the modulation of myocardial hypertrophy in animal models and in humans, but ER expression in the human heart and its relation to hypertrophy-mediated gene expression have not yet been analyzed. We therefore investigated sex- and disease-dependent alterations of myocardial ER expression in human aortic stenosis together with the expression of hypertrophy-related genes
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