To assess the effects during cardiac development of mutations that cause human cardiomyopathy, we modeled a sarcomeric gene mutation in the embryonic zebrafish. We designed morpholino antisense oligonucleotides targeting the exon 13 splice donor site in the zebrafish cardiac troponin T (tnnt2) gene, in order to precisely recapitulate a human TNNT2 mutation that causes hypertrophic cardiomyopathy (HCM). HCM is a disease characterized by myocardial hypertrophy, myocyte and myofibrillar disarray, as well as an increased risk of sudden death. Similar to humans with HCM, the morphant zebrafish embryos displayed sarcomere disarray and there was a robust induction of myocardial hypertrophic pathways. Microarray analysis uncovered a number of share...
Tese de doutoramento, Ciências Biomédicas (Biologia Celular e Molecular), Universidade de Lisboa, Fa...
OBJECTIVE: To identify novel dilated cardiomyopathy (DCM) causing genes, and to elucidate the pathol...
Over the past decade, our understanding of cardiomyopathies has improved dramatically, due to improv...
SUMMARY To assess the effects during cardiac development of mutations that cause human cardiomyopath...
Background – Mutations of cardiac troponin C (cTnC) can cause dilated cardiomyopathy in humans. We a...
Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, incl...
The adult zebrafish is an emerging vertebrate model for studying human cardiomyopathies; however, wh...
Hypertrophic cardiomyopathy (HCM), that clinically manifests as an enlarged heart is a highly preval...
The demonstrated number 1 killer in the world is cardiovascular disease, with inherited cardiomyopat...
Adult zebrafish is an emerging vertebrate model for studying genetic basis of cardiomyopathies; but ...
Background: An adult zebrafish heart possesses a high capacity of regeneration. However, it has been...
Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mut...
AbstractVarious hypotheses have been proposed to explain the molecule processes of sarcomere assembl...
Hypertrophic cardiomyopathy (HCM) is a prevalent genetic cardiovascular disease affecting 1:500 indi...
Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy (HCM), a disord...
Tese de doutoramento, Ciências Biomédicas (Biologia Celular e Molecular), Universidade de Lisboa, Fa...
OBJECTIVE: To identify novel dilated cardiomyopathy (DCM) causing genes, and to elucidate the pathol...
Over the past decade, our understanding of cardiomyopathies has improved dramatically, due to improv...
SUMMARY To assess the effects during cardiac development of mutations that cause human cardiomyopath...
Background – Mutations of cardiac troponin C (cTnC) can cause dilated cardiomyopathy in humans. We a...
Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, incl...
The adult zebrafish is an emerging vertebrate model for studying human cardiomyopathies; however, wh...
Hypertrophic cardiomyopathy (HCM), that clinically manifests as an enlarged heart is a highly preval...
The demonstrated number 1 killer in the world is cardiovascular disease, with inherited cardiomyopat...
Adult zebrafish is an emerging vertebrate model for studying genetic basis of cardiomyopathies; but ...
Background: An adult zebrafish heart possesses a high capacity of regeneration. However, it has been...
Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mut...
AbstractVarious hypotheses have been proposed to explain the molecule processes of sarcomere assembl...
Hypertrophic cardiomyopathy (HCM) is a prevalent genetic cardiovascular disease affecting 1:500 indi...
Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy (HCM), a disord...
Tese de doutoramento, Ciências Biomédicas (Biologia Celular e Molecular), Universidade de Lisboa, Fa...
OBJECTIVE: To identify novel dilated cardiomyopathy (DCM) causing genes, and to elucidate the pathol...
Over the past decade, our understanding of cardiomyopathies has improved dramatically, due to improv...