The developing submandibular salivary gland (SMG) is a well-studied model for tissue interactions and branching morphogenesis. Its development shares similar features with other ectodermal appendages such as hair and tooth. The ectodysplasin (Eda) pathway is essential for the formation and function of several ectodermal organs. Mutations in the signaling components of the Eda pathway lead to a human syndrome known as hypohidrotic ectodermal dysplasia (HED), which is characterized by missing and malformed teeth, sparse hair and reduced sweating. Individuals with HED suffer also from dry mouth because of reduced saliva flow. In order to understand the underlying mechanism, we analyzed salivary gland development in mouse models with altered Ed...
Ectodysplasin receptor Edar and its ligand Eda A1, as well as their related receptor Xedar and ligan...
AbstractBranching morphogenesis is a molecularly conserved mechanism that is adopted by several orga...
Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of...
Hypohidrotic ectodermal dysplasia (HED) is characterized by defective ectodermal organ development. ...
A universally conserved process called branching morphogenesis generates the final tree-like structu...
AbstractAll ectodermal organs, e.g. hair, teeth, and many exocrine glands, originate from two adjace...
AbstractEctodermal dysplasia syndromes affect the development of several organs, including hair, tee...
AbstractThe development of epithelial appendages, including hairs, glands and teeth starts from ecto...
AbstractOrgans developing as ectodermal appendages share similar early morphogenesis and molecular m...
Summary: Branching morphogenesis is an important developmental process for many organs, including th...
Ectodermal organogenesis is regulated by inductive and reciprocal signalling cascades that involve m...
Mammalian salivary glands synthesize and secrete saliva via a vast interconnected network of epithel...
AbstractDespite their importance to oral health, the mechanisms of minor salivary gland (SG) develop...
Salivary submandibular gland (SMG) morphogenesis is regulated by the functionalintegration of stage-...
Ectodysplasin (Eda), a member of the tumor necrosis factor (Tnf) family, regulates skin appendage mo...
Ectodysplasin receptor Edar and its ligand Eda A1, as well as their related receptor Xedar and ligan...
AbstractBranching morphogenesis is a molecularly conserved mechanism that is adopted by several orga...
Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of...
Hypohidrotic ectodermal dysplasia (HED) is characterized by defective ectodermal organ development. ...
A universally conserved process called branching morphogenesis generates the final tree-like structu...
AbstractAll ectodermal organs, e.g. hair, teeth, and many exocrine glands, originate from two adjace...
AbstractEctodermal dysplasia syndromes affect the development of several organs, including hair, tee...
AbstractThe development of epithelial appendages, including hairs, glands and teeth starts from ecto...
AbstractOrgans developing as ectodermal appendages share similar early morphogenesis and molecular m...
Summary: Branching morphogenesis is an important developmental process for many organs, including th...
Ectodermal organogenesis is regulated by inductive and reciprocal signalling cascades that involve m...
Mammalian salivary glands synthesize and secrete saliva via a vast interconnected network of epithel...
AbstractDespite their importance to oral health, the mechanisms of minor salivary gland (SG) develop...
Salivary submandibular gland (SMG) morphogenesis is regulated by the functionalintegration of stage-...
Ectodysplasin (Eda), a member of the tumor necrosis factor (Tnf) family, regulates skin appendage mo...
Ectodysplasin receptor Edar and its ligand Eda A1, as well as their related receptor Xedar and ligan...
AbstractBranching morphogenesis is a molecularly conserved mechanism that is adopted by several orga...
Human WNT10A mutations are associated with developmental tooth abnormalities and adolescent onset of...