Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and women
- Pischon, T.
- Pai, J.K.
- Manson, J.E.
- Hu, F.B.
- Rexrode, K.M.
- Hunter, D.
- Rimm, E.B.
Publication date
August 2005
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
Activation of the peroxisome proliferator-activated receptor-gamma (PPARgamma) improves insulin sensitivity and exerts antiatherogenic effects. A common alanine for proline substitution at codon 12 in the PPARG2 gene is related to lower receptor activity. Studies suggest that the A12 allele is associated with reduced risk of type 2 diabetes; however, data on the risk of coronary heart disease (CHD) are scarce and controversial
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