Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance
- Jarius, S.
- Franciotta, D.
- Paul, F.
- Ruprecht, K.
- Bergamaschi, R.
- Rommer, P.S.
- Reuss, R.
- Probst, C.
- Kristoferitsch, W.
- Wandinger, K.P.
- Wildemann, B.
Publication date
September 2010
DOI Publisher
Springer Science and Business Media LLC Language
EnglishAbstract
In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests that AQP4-Ab are directly involved in the immunopathogenesis of NMO
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