Although the identification and characterization of translocations have rapidly increased, little is known about the mechanisms of how translocations occur in vivo. We used anaplastic large cell lymphoma (ALCL) with and without the characteristic t(2;5)(p23;q35) translocation to study the mechanisms of formation of translocations and of ALCL transformation. We report deregulation of several genes located near the ALCL translocation breakpoint, regardless of whether the tumor contains the t(2;5). The affected genes include the oncogenic transcription factor Fra2 (located on 2p23), the HLH protein Id2 (2p25), and the oncogenic tyrosine kinase CSF1-receptor (5q33.1). Their up-regulation promotes cell survival and repression of T cell-specific ...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...
Translocations involving the anaplastic lymphoma kinase (ALK) gene locus on chromosome 2p23 were fir...
The discovery by Morris SW et al. in 1994 of the genes contributing to the t(2;5)(p23;q35) transloca...
WOS: 000286426300023PubMed ID: 21030553The genetics of peripheral T-cell lymphomas are poorly unders...
The precise cellular origin and the pathogenetic mechanism(s) leading to the neoplastic transformati...
The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation...
Les translocations chromosomiques sont des événements cellulaires rares signatures de nombreux cance...
Systemic anaplastic large cell lymphoma (ALCL) is subtyped into ALK-positive ALCL and ALK-negative A...
SummaryA systematic characterization of the genetic alterations driving ALCLs has not been performed...
Expression of ALK protein by lymphoid cells and the description of variant ana-plastic lymphoma kina...
To determine the significance of the t(2;5)(p23;q35) translocation in nodal and extranodal anaplasti...
The majority of anaplastic large cell lymphomas (ALCL) are associated with chromosomal abnormalities...
Anaplastic large cell lymphoma (ALCL) is a main type of T-cell lymphomas and comprises three distinc...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...
Translocations involving the anaplastic lymphoma kinase (ALK) gene locus on chromosome 2p23 were fir...
The discovery by Morris SW et al. in 1994 of the genes contributing to the t(2;5)(p23;q35) transloca...
WOS: 000286426300023PubMed ID: 21030553The genetics of peripheral T-cell lymphomas are poorly unders...
The precise cellular origin and the pathogenetic mechanism(s) leading to the neoplastic transformati...
The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation...
Les translocations chromosomiques sont des événements cellulaires rares signatures de nombreux cance...
Systemic anaplastic large cell lymphoma (ALCL) is subtyped into ALK-positive ALCL and ALK-negative A...
SummaryA systematic characterization of the genetic alterations driving ALCLs has not been performed...
Expression of ALK protein by lymphoid cells and the description of variant ana-plastic lymphoma kina...
To determine the significance of the t(2;5)(p23;q35) translocation in nodal and extranodal anaplasti...
The majority of anaplastic large cell lymphomas (ALCL) are associated with chromosomal abnormalities...
Anaplastic large cell lymphoma (ALCL) is a main type of T-cell lymphomas and comprises three distinc...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a rel...