Tcf/Lef HMG box transcription factors are nuclear effectors of the canonical Wnt signaling pathway, which function in cell fate specification. Lef1 is required for the development of tissues and organs that depend on epithelial mesenchymal interactions. Here, we report the effects of lef1 loss of function on early development in X. tropicalis. Depletion of lef1 affects gene expression already during gastrulation and results in abnormal differentiation of cells derived from ectoderm and mesoderm. At tail bud stages, the epidermis was devoid of ciliated cells and derivatives of the neural crest, e.g. melanocytes and cephalic ganglia were absent. In the Central Nervous System, nerve fibers were absent or underdeveloped. The development of the ...
AbstractInvertebrates express a multitude of Wnt ligands and all Wnt/β-catenin signaling pathways co...
AbstractInductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin...
Xenopus myotome is formed by a first medial and lateral myogenesis directly arising from the presomi...
Tcf/Lef HMG box transcription factors are nuclear effectors of the canonical Wnt signaling pathway, ...
AbstractWnt signaling functions repeatedly during embryonic development to induce different but spec...
We have cloned the Xenopus laevis homologue of the LFB3/HNF1β transcription factor. RNase protection...
In Xenopus, specification of the three germ layers is one of the earliest developmental decisions oc...
AbstractThe Xenopus nodal-related 3 gene (Xnr3) is expressed in the Spemann organizer of the embryo ...
AbstractCanonical Wnt signals have been implicated in multiple events during early embryogenesis, in...
AbstractThough the Wnt/β-catenin signaling pathway is known to play key roles during Xenopus axis sp...
In Xenopus, specification of the three germ layers is one of the earliest developmental decisions oc...
<div><p>In <i>Xenopus</i>, specification of the three germ layers is one of the earliest development...
Inductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin appenda...
TCF1 belongs to the family of LEF1/TCF transcription factors that regulate gene expression downstrea...
XHNF1β is a homeobox-containing gene initially expressed at the blastula stage in the vegetal part o...
AbstractInvertebrates express a multitude of Wnt ligands and all Wnt/β-catenin signaling pathways co...
AbstractInductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin...
Xenopus myotome is formed by a first medial and lateral myogenesis directly arising from the presomi...
Tcf/Lef HMG box transcription factors are nuclear effectors of the canonical Wnt signaling pathway, ...
AbstractWnt signaling functions repeatedly during embryonic development to induce different but spec...
We have cloned the Xenopus laevis homologue of the LFB3/HNF1β transcription factor. RNase protection...
In Xenopus, specification of the three germ layers is one of the earliest developmental decisions oc...
AbstractThe Xenopus nodal-related 3 gene (Xnr3) is expressed in the Spemann organizer of the embryo ...
AbstractCanonical Wnt signals have been implicated in multiple events during early embryogenesis, in...
AbstractThough the Wnt/β-catenin signaling pathway is known to play key roles during Xenopus axis sp...
In Xenopus, specification of the three germ layers is one of the earliest developmental decisions oc...
<div><p>In <i>Xenopus</i>, specification of the three germ layers is one of the earliest development...
Inductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin appenda...
TCF1 belongs to the family of LEF1/TCF transcription factors that regulate gene expression downstrea...
XHNF1β is a homeobox-containing gene initially expressed at the blastula stage in the vegetal part o...
AbstractInvertebrates express a multitude of Wnt ligands and all Wnt/β-catenin signaling pathways co...
AbstractInductive reciprocal signaling between mesenchymal and adjacent epithelia gives rise to skin...
Xenopus myotome is formed by a first medial and lateral myogenesis directly arising from the presomi...