Objective:The endocannabinoid system (ECS) promotes weight gain and obesity-associated metabolic changes. Weight loss interventions may influence obesity-associated risk indirectly through modulation of the peripheral ECS. We investigated the effect of acute and chronic treatment with sibutramine on components of the peripheral ECS.Methods and Procedures:Twenty obese otherwise healthy patients received randomized, double-blind, crossover treatment with placebo and 15 mg/day sibutramine for 5 days each, followed by 12 weeks open-label sibutramine treatment. We determined circulating anandamide and 2-arachidonoylglycerol and expression levels of endocannabinoid genes in subcutaneous abdominal adipose tissue biopsies.Results:Body weight was st...
Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is as...
The endocannabinoid system elicits multiple physiologic functions that are not fully understood. Ant...
An activation of the endocannabinoid system (ECS) in obesity with increased concentrations of endoca...
Obesity is the main risk factor for the development of type 2 diabetes. Activation of the central en...
The endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (CB) CB1...
The endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (CB) CB1...
The endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (CB) CB1...
Obesity is associated with metabolic complications including insulin resistance, dyslipidemia and hy...
OBJECTIVE: Endocannabinoids and neuropeptide Y (NPY) promote energy storage via central and peripher...
Context: Cannabinoid CB1 receptor blockade decreases weight and hyperinsulinemia in obese animals an...
Objective: To evaluate the effects of weight loss on endocannabinoids, cardiometabolic and psycholog...
Maintenance of body weight is fundamental to maintain one’s health and to promote longevity. N...
Maintenance of body weight is fundamental to maintain one’s health and to promote longevity. N...
Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is as...
Dysfunction of the endocannabinoid system (ECS) has been identified in metabolic disease. Cannabinoi...
Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is as...
The endocannabinoid system elicits multiple physiologic functions that are not fully understood. Ant...
An activation of the endocannabinoid system (ECS) in obesity with increased concentrations of endoca...
Obesity is the main risk factor for the development of type 2 diabetes. Activation of the central en...
The endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (CB) CB1...
The endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (CB) CB1...
The endocannabinoids are endogenous lipids capable of binding to both cannabinoid receptors (CB) CB1...
Obesity is associated with metabolic complications including insulin resistance, dyslipidemia and hy...
OBJECTIVE: Endocannabinoids and neuropeptide Y (NPY) promote energy storage via central and peripher...
Context: Cannabinoid CB1 receptor blockade decreases weight and hyperinsulinemia in obese animals an...
Objective: To evaluate the effects of weight loss on endocannabinoids, cardiometabolic and psycholog...
Maintenance of body weight is fundamental to maintain one’s health and to promote longevity. N...
Maintenance of body weight is fundamental to maintain one’s health and to promote longevity. N...
Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is as...
Dysfunction of the endocannabinoid system (ECS) has been identified in metabolic disease. Cannabinoi...
Growing evidence suggests that pathological overactivation of the endocannabinoid system (ECS) is as...
The endocannabinoid system elicits multiple physiologic functions that are not fully understood. Ant...
An activation of the endocannabinoid system (ECS) in obesity with increased concentrations of endoca...