The balance between norepinephrine (NE) synthesis, release, and reuptake is disrupted after acute myocardial infarction resulting in elevated extracellular NE. Stimulation of sympathetic neurons in vitro increases NE synthesis and the synthetic enzyme tyrosine hydroxylase (TH) to a greater extent than it increases NE reuptake and the NE transporter (NET) which removes NE from the extracellular space. We used TGR(ASrAOGEN) transgenic rats, which lack post-infarct sympathetic hyperactivity, to test the hypothesis that increased cardiac sympathetic nerve activity accounts for the imbalance in TH and NET expression in these neurons after myocardial infarction. TH and NET mRNA levels were identical in the stellate ganglia of unoperated TGR(ASrAO...
The work presented in this thesis examines the role of cardiac sympathetic signalling in the develop...
Uptake of norepinephrine via the neuronal norepinephrine transporter is reduced in the heart during ...
Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocard...
Myocardial infarction causes a heterogeneity of noradrenergic transmission that contributes to the d...
Central mechanisms involving aldosterone - mineralocorticoid receptor (MR) activation mediate the in...
Sympathetic and parasympathetic control of the heart is a classic example of norepinephrine (NE) and...
<p>(<b>A</b>) Representative Western-blot analysis of NGF expression in the ischemic area of infarct...
The neuropeptide galanin is elevated in the cardiac sympathetic innervation after myocardial infarct...
Postinfarct sympathetic hyperactivity differentially stimulates expression of tyrosine hydroxylase a...
Hypertension is associated with enhanced cardiac sympathetic transmission, although the exact mechan...
Sympathetic hyperinnervation occurs in human ventricular tissue after myocardial infarction and may ...
In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by deple...
Hypertension is associated with enhanced cardiac sympathetic transmission, although the exact mechan...
The work presented in this thesis examines the role of cardiac sympathetic signalling in the develop...
A role for cardiac sympathetic hyperinnervation in arrhythmogenesis after myocardial infarction (MI)...
The work presented in this thesis examines the role of cardiac sympathetic signalling in the develop...
Uptake of norepinephrine via the neuronal norepinephrine transporter is reduced in the heart during ...
Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocard...
Myocardial infarction causes a heterogeneity of noradrenergic transmission that contributes to the d...
Central mechanisms involving aldosterone - mineralocorticoid receptor (MR) activation mediate the in...
Sympathetic and parasympathetic control of the heart is a classic example of norepinephrine (NE) and...
<p>(<b>A</b>) Representative Western-blot analysis of NGF expression in the ischemic area of infarct...
The neuropeptide galanin is elevated in the cardiac sympathetic innervation after myocardial infarct...
Postinfarct sympathetic hyperactivity differentially stimulates expression of tyrosine hydroxylase a...
Hypertension is associated with enhanced cardiac sympathetic transmission, although the exact mechan...
Sympathetic hyperinnervation occurs in human ventricular tissue after myocardial infarction and may ...
In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by deple...
Hypertension is associated with enhanced cardiac sympathetic transmission, although the exact mechan...
The work presented in this thesis examines the role of cardiac sympathetic signalling in the develop...
A role for cardiac sympathetic hyperinnervation in arrhythmogenesis after myocardial infarction (MI)...
The work presented in this thesis examines the role of cardiac sympathetic signalling in the develop...
Uptake of norepinephrine via the neuronal norepinephrine transporter is reduced in the heart during ...
Sympathetic nerve and vagus nerve remodeling play an important part in cardiac function post-myocard...