Several lines of evidence suggest that chromosome 8 is likely to harbor tumor-suppressor genes involved in breast cancer. We showed previously that microcell-mediated transfer of human chromosome 8 into breast cancer cell line MDA-MB-231 resulted in reversion of these cells to tumorigenicity and was accompanied by changes in the expression of a breast cancer-relevant gene set. In the present study, we demonstrated that transfer of human chromosome 8 into another breast cancer cell line, CAL51, strongly reduced the tumorigenic potential of these cells. Loss of the transferred chromosome 8 resulted in reappearance of the CAL51 phenotype. Microarray analysis identified 78 probe sets differentially expressed in the hybrids compared with in the ...
Loss of heterozygosity (LOH) on the short arm of chromosome 8, at 8p 12-p23, is one of the most freq...
Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14,...
Chromosomal losses involving the short arm of chromosome 8 are frequent in a variety of tumor types,...
Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors. Fi...
Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors. Fi...
Breast cancer development is associated with several genetic abnormalities. Loss of heterozygosity i...
Development of breast cancer has been associated with deletions at multiple chromosomal regions, inc...
Loss of genetic material from chromosome arm 8p occurs commonly in breast carcinomas, suggesting tha...
The short arm of chromosome 8 undergoes frequent loss of heterozygosity (LOH) in ovarian adenocarcin...
Recent evidence obtained by cytogenetic and molecular studies indicates that in breast cancer chromo...
The aim of this project was to characterise the rearrangements of 8p in multiple tumours and identif...
Large-scale heterozygous deletions are a hallmark of cancer genome. Although with high recurrent fre...
Previous studies have shown that transfer of chromosome 17 suppresses the tumorigenic phenotype of t...
International audienceSeveral genes, most of them unknown, of the short arm of chromosome 8 are invo...
Chromosomal losses involving the short arm of chromosome 8 are frequent in a variety of tumour types...
Loss of heterozygosity (LOH) on the short arm of chromosome 8, at 8p 12-p23, is one of the most freq...
Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14,...
Chromosomal losses involving the short arm of chromosome 8 are frequent in a variety of tumor types,...
Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors. Fi...
Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors. Fi...
Breast cancer development is associated with several genetic abnormalities. Loss of heterozygosity i...
Development of breast cancer has been associated with deletions at multiple chromosomal regions, inc...
Loss of genetic material from chromosome arm 8p occurs commonly in breast carcinomas, suggesting tha...
The short arm of chromosome 8 undergoes frequent loss of heterozygosity (LOH) in ovarian adenocarcin...
Recent evidence obtained by cytogenetic and molecular studies indicates that in breast cancer chromo...
The aim of this project was to characterise the rearrangements of 8p in multiple tumours and identif...
Large-scale heterozygous deletions are a hallmark of cancer genome. Although with high recurrent fre...
Previous studies have shown that transfer of chromosome 17 suppresses the tumorigenic phenotype of t...
International audienceSeveral genes, most of them unknown, of the short arm of chromosome 8 are invo...
Chromosomal losses involving the short arm of chromosome 8 are frequent in a variety of tumour types...
Loss of heterozygosity (LOH) on the short arm of chromosome 8, at 8p 12-p23, is one of the most freq...
Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14,...
Chromosomal losses involving the short arm of chromosome 8 are frequent in a variety of tumor types,...