Histopathological features of bisphosphonate-associated osteonecrosis: findings in patients treated with partial mandibulectomies

The present study investigated the histopathologic and radiographic features of stage 3 bisphosphonate-associated osteonecrosis of the jaw (BAONJ) in patients who were treated with partial mandibulectomies. Bisphosphonates had been orally administered to 10 patients with osteoporosis and intravenously administered to 1 patient with metastatic carcinoma. On radiographic images, massive osteolysis and periosteal bone formations were conspicuous, and a thin mandibular cortical width was observed in 5 of 10 osteoporosis patients despite the previous use of bisphosphonate. Microscopically, the mandibulectomy specimens of the patients could be divided into 4 distinct layers. Although there were few differences in overall histologic features between BAONJ and chronic suppurative osteomyelitis, a notable number of osteoclasts were found detached from the bony trabeculae in BAONJ.OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000004825/1SEQ:1PERF_CD:SNU2012-01EVAL_ITEM_CD:102USER_ID:0000004825ADJUST_YN:YEMP_ID:A075646DEPT_CD:861CITE_RATE:1.457FILENAME:첨부된 내역이 없습니다.DEPT_NM:치의학과EMAIL:hongsd@snu.ac.krSCOPUS_YN:YCONFIRM: