Comparison of maximal elastance and systolic wall thickening using arterial tonometry and gated myocardial SPECT in patients undergoing coronary artery bypass grafting

Myocardial SPECT using (99m)Tc-sestamibi, (99m)Tc-tetrofosmin, (201)Thallium is widely used in nuclear cardiology. Left ventricular systolic wall thickening (SWT) by SPECT and regional maximal elastance (rE(max)) using arterial tonometry were compared. rE(max) was calculated from time-pressure and time-volume curves. In normal heart, improvement of SWT was 4.1 +/- 11%, while 6.0 +/- 16% in dilated heart. Improvement of rE(max) was 0.67 +/- 1.0 mmHg/mL in normal heart and 0.32 +/- 0.7 mmHg/mL in dilated heart (p < 0.05). rE(max) can be an alternative variable as an index of regional contractility. (C) 2009 Elsevier Ltd. All rights reserved.This studywassupportedbyClinicalResearchInstituteSeoul NationalUniversityHospital(04-2006-015-0).Nakajima K, 2007, EUR J NUCL MED MOL I, V34, P1088, DOI 10.1007/s00259-006-0321-1Suga H, 2003, CLIN EXP PHARMACOL P, V30, P580Suga H, 2003, J BIOMECH, V36, P713, DOI 10.1016/S0021-9290(02)00449-9LEE E, 2003, PLOS BIOL, V1, P10LEE BI, 2003, KOREAN J NUCL MED, V37, P355LEE BI, 2002, P IEEE MIC M10 29Sharir T, 2001, J NUCL MED, V42, P1630Paeng JC, 2001, J NUCL MED, V42, P695KIM KM, 2001, KOREAN J NUCL MED, V35, P152Lee DS, 1999, J NUCL CARDIOL, V6, P657Germano G, 1997, J AM COLL CARDIOL, V30, P1360SENZAKI H, 1996, CIRCULATION, V94, P506GERMANO G, 1995, J NUCL MED, V36, P2138SUGA H, 1994, JPN HEART J, V35, P263