Hepatic Resection Versus Radiofrequency Ablation for Very Early Stage Hepatocellular Carcinoma: A Markov Model Analysis

No adequate randomized trials have been reported for a comparison between hepatic resection (HR) versus radiofrequency ablation (RFA) for the treatment of patients with very early stage hepatocellular carcinoma (HCC), defined as an asymptomatic solitary HCC 0.3%. The 95% confidence intervals for the difference in overall survival were -0.18-0.18 years between group I and II, 0.06-0.36 years between group I and III, and 0.13-0.30 years between group II and III, respectively. Conclusion: Primary percutaneous RFA followed by HR for cases of initial local failure was nearly identical to HR for the overall survival of compensated cirrhotic patients with very early stage HCC. (HEPATOLOGY 2010; 51:1284-1290.)Molinari M, 2009, AM J SURG, V198, P396, DOI 10.1016/j.amjsurg.2009.01.016Bruno S, 2009, AM J GASTROENTEROL, V104, P1147, DOI 10.1038/ajg.2009.31Farinati F, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-33LAI CH, 2009, WORLD J SURG, V33, P2150Bell BP, 2008, AM J GASTROENTEROL, V103, P2727, DOI 10.1111/j.1572-0241.2008.02071.xAbu-Hilal M, 2008, J GASTROINTEST SURG, V12, P1521, DOI 10.1007/s11605-008-0553-4Naimark DMJ, 2008, MED DECIS MAKING, V28, P706, DOI 10.1177/0272989X08315241Eguchi S, 2008, SURGERY, V143, P469, DOI 10.1016/j.surg.2007.12.003Livraghi T, 2008, HEPATOLOGY, V47, P82, DOI 10.1002/hep.21933Minagawa M, 2007, ANN SURG, V245, P909, DOI 10.1097/01.sla.0000254368.65878.daNakazawa T, 2007, AM J ROENTGENOL, V188, P480, DOI 10.2214/AJR.05.2079LUPO L, 2007, HPB OXFORD, V9, P429Sangiovanni A, 2006, HEPATOLOGY, V43, P1303, DOI 10.1002/hep.21176Chen MS, 2006, ANN SURG, V243, P321, DOI 10.1097/01.sla.0000201480.65519.b8LU MD, 2006, ZHONGHUA YI XUE ZA Z, V86*DEP HLTH HUM SERV, 2006, NAT VIT STAT REP, V54Bruix J, 2005, HEPATOLOGY, V42, P1208, DOI 10.1002/hep20933Akahane M, 2005, RADIOGRAPHICS, V25, pS57, DOI 10.1148/rg.25.si055505Lin SM, 2005, GUT, V54, P1151, DOI 10.1136/gut.2004.045203Livraghi T, 2005, BRIT J SURG, V92, P856, DOI 10.1002/bjs.4986Tateishi R, 2005, CANCER, V103, P1201, DOI 10.1002/cncr.20892Hong SN, 2005, J CLIN GASTROENTEROL, V39, P247Lin SM, 2004, GASTROENTEROLOGY, V127, P1714, DOI 10.1053/j.gastro.2004.09.003Sala M, 2004, LIVER TRANSPLANT, V10, P1294, DOI 10.1002/lt.20202Ikai I, 2004, CANCER, V101, P796, DOI 10.1002/cncr.20426Shimozawa N, 2004, J AM COLL SURGEONS, V198, P356, DOI 10.1016/j.jamcollsurg.2003.10.017Choi DI, 2004, RADIOLOGY, V230, P135, DOI 10.1148/radiol.2301021182Komorizono Y, 2003, CANCER, V97, P1253, DOI 10.1002/cncr.11168Llovet JM, 2003, HEPATOLOGY, V37, P429, DOI 10.1053/jhep.2003.50047Rhim H, 2003, RADIOGRAPHICS, V23, P123, DOI 10.1148/rg.231025054RHIM H, 2003, RADIOGRAPHICS, V23, P134Mulier S, 2002, BRIT J SURG, V89, P1206Elias D, 2002, BRIT J SURG, V89, P752Wayne JD, 2002, ANN SURG, V235, P722Llovet JM, 2001, HEPATOLOGY, V33, P1124Zhou XD, 2001, CANCER, V91, P1479Arii S, 2000, HEPATOLOGY, V32, P1224, DOI 10.1053/jhep.2000.20456Wood TF, 2000, ANN SURG ONCOL, V7, P593Maeda T, 2000, HEPATO-GASTROENTEROL, V47, P1063HUNINK MG, 2000, MED DECIS MAKING, V20, P135LIVRAGHI T, 2000, RADIOLOGY, V217, P27Llovet JM, 1999, HEPATOLOGY, V30, P1434Fong YM, 1999, ANN SURG, V229, P790Poon RTP, 1999, ANN SURG, V229, P216Takayama T, 1998, HEPATOLOGY, V28, P1241Ryu M, 1997, JPN J CLIN ONCOL, V27, P251Takenaka K, 1996, ARCH SURG-CHICAGO, V131, P71LIVRAGHI T, 1995, J HEPATOL, V22, P522IKEDA K, 1993, CANCER, V71, P19BECK JR, 1982, AM J MED, V73, P8831