Korean normative database for time domain optical coherence tomography to detect localized retinal nerve fiber layer defects (preliminary study)

To establish a Korean normative database of retinal nerve fiber layer (RNFL) thickness. Data was collected from 103 healthy volunteers. Total ophthalmologic examinations, including fast RNFL thickness analysis by time domain optical coherence tomography (STRATUS OCT) were performed. The RNFL thickness of 64 glaucoma patients with localized RNFL defects and 48 independent healthy subjects were collected. The RNFL thickness of both the glaucoma patients and the healthy subjects was evaluated using both normative databases. The average RNFL thickness of Koreans was 108.3 +/- 10.3 mu m. The sensitivity rates recorded in the Korean normative database with 5% and 1% significance were 0.984 and 0.984, with specificity values of 0.938 and 1.000. By comparison, the sensitivity rates in the conventional normative database with 5% and 1% significance are 0.984 and 0.953, and the specificity values are 1.000 and 1.000. In detecting localized RNFL defects, the Korean database showed higher sensitivity than the conventional database.Lee EJ, 2009, INVEST OPHTH VIS SCI, V50, P662, DOI 10.1167/iovs.08-1682Kim TW, 2007, INVEST OPHTH VIS SCI, V48, P1635, DOI 10.1167/iovs.06-0800Sihota R, 2006, INVEST OPHTH VIS SCI, V47, P2006, DOI 10.1167/iovs.05-1102Jeoung JW, 2005, OPHTHALMOLOGY, V112, P2157, DOI 10.1016/j.ophtha.2005.07.012Racette L, 2005, ARCH OPHTHALMOL-CHIC, V123, P1547Wilson MR, 2005, MED CLIN N AM, V89, P795, DOI 10.1016/j.mcna.2005.02.002Aung T, 2005, ARCH OPHTHALMOL-CHIC, V123, P527WADHWA SD, 2005, CURR OPIN OPHTHALMOL, V16, P101Budenz DL, 2005, OPHTHALMOLOGY, V112, P3, DOI 10.1016/j.ophtha.2004.06.039Nagasubramanian S, 2004, EUR J OPHTHALMOL, V14, P501Friedman DS, 2004, ARCH OPHTHALMOL-CHIC, V122, P1019MANDAVI KN, 2004, AM J OPHTHALMOL, V137, P228Varma R, 2003, INVEST OPHTH VIS SCI, V44, P3369, DOI 10.1167/iovs.02-0975Mok KH, 2002, J GLAUCOMA, V11, P481Bowd C, 2001, INVEST OPHTH VIS SCI, V42, P1993MARDIN CY, 2001, CURR OPIN OPHTHALMOL, V12, P100Poinoosawmy D, 1997, BRIT J OPHTHALMOL, V81, P350MIKELBERG FS, 1995, OPHTHALMOLOGY, V102, P342TUULONEN A, 1993, OPHTHALMOLOGY, V100, P587LEE JB, 1993, J KOREAN OPHTHALMOL, V34, P65SOMMER A, 1984, ARCH OPHTHALMOL-CHIC, V102, P1766QUIGLEY HA, 1982, ARCH OPHTHALMOL-CHIC, V100, P135QUIGLEY HA, 1982, ARCH OPHTHALMOL-CHIC, V100, P807QUIGLEY HA, 1980, ARCH OPHTHALMOL-CHIC, V98, P1564SOMMER A, 1977, ARCH OPHTHALMOL-CHIC, V95, P2149PATELLA M, STRATUS OCT ESTABLIS