Effects of Mn concentration on the ac magnetically induced heating characteristics of superparamagnetic Mn(x)Zn(1-x)Fe(2)O(4) nanoparticles for hyperthermia

The effects of Mn(2+) cation concentration on the ac magnetically induced heating characteristics and the magnetic properties of superparamagnetic Mn(x)Zn(1-x)Fe(2)O(4) nanoparticles (SPNPs) were investigated to explore the biotechnical feasibility as a hyperthermia agent. Among the Mn(x)Zn(1-x)Fe(2)O(4) SPNPs, the Mn(0.5)Zn(0.5)Fe(2)O(4) SPNP showed the highest ac magnetically induced heating temperature (Delta T(ac,mag)), the highest specific absorption rate (SAR), and the highest biocompatibility. The higher out of phase susceptibility (chi(``)(m)) value and the higher chemical stability systematically controlled by the replacement of Zn(2+) cations by the Mn(2+) cations on the A-site (tetrahedral site) are the primary physical reason for the promising biotechnical properties of Mn(0.5)Zn(0.5)Fe(2)O(4) SPNP.Pankhurst QA, 2009, J PHYS D APPL PHYS, V42, DOI 10.1088/0022-3727/42/22/224001Hosono T, 2009, J MAGN MAGN MATER, V321, P3019, DOI 10.1016/j.jmmm.2009.04.061LEE SW, 2008, 53 ANN C MAGN MAGN MXuan YM, 2007, J MAGN MAGN MATER, V312, P464, DOI 10.1016/j.jmmm.2006.11.200Bae S, 2006, APPL PHYS LETT, V89, DOI 10.1063/1.2420769Wust P, 2006, INT J HYPERTHER, V22, P673, DOI 10.1080/02656730601106037Okawa K, 2006, J APPL PHYS, V99, DOI 10.1063/1.2173208GOLDMAN A, 2006, MODERN FERRITE TECHNGonzales M, 2005, J MAGN MAGN MATER, V293, P265, DOI 10.1016/j.jmmm.2005.02.020Sun SH, 2004, J AM CHEM SOC, V126, P273, DOI 10.1021/ja0380852Rosensweig RE, 2002, J MAGN MAGN MATER, V252, P370Moroz P, 2002, INT J HYPERTHER, V18, P267, DOI 10.1080/02656730110108785JOHN E, 2001, A Z GUIDE ELEMENTSRath C, 1999, J MAGN MAGN MATER, V202, P77Sugimoto M, 1999, J AM CERAM SOC, V82, P269