Radiosurgery for brain metastasis from advanced gastric cancer

We retrospectively evaluated the survival of patients with brain metastases from advanced gastric cancer (AGC) after radiosurgery (RS). Between 1998 and 2007, a total of 11 patients (median age, 61 years; range, 36-70) were diagnosed with brain metastasis from AGC and treated with RS. Each of five (46%) patients had two brain metastases. The median volume of the 16 lesions was 2.9 cm(3) (range, 0.1-33.8). The median marginal dose prescribed was 20 Gy (range, 10-25) at the 50% isodose line. RS was the primary treatment for brain metastases in six patients. As of February 28, 2008, eight (73%) patients had died, and three (27%) were living with stable disease. The median survival time was 17.0 +/- 3.9 months (95% CI, 9.4-24.6). The median progression-free survival time was 9.0 +/- 2.5 months (95% CI, 4.2-13.8). Patients who did not undergo WBRT died within 8 months, and the other six patients treated with WBRT at various time intervals from the diagnosis of brain metastases survived, with a median survival time of 19.0 +/- 3.4 months (95% CI, 12.4-25.6). Radiosurgery seems to be a good alternative to surgical resection for patients with brain metastases from AGC, when performed in conjunction with WBRT.Al-Shamy G, 2009, J NEURO-ONCOL, V92, P275, DOI 10.1007/s11060-009-9839-yHan JH, 2008, INT J RADIAT ONCOL, V72, P1324, DOI 10.1016/j.ijrobp.2008.03.028Lee JL, 2004, J NEURO-ONCOL, V66, P167Hasegawa T, 2003, SURG NEUROL, V60, P506, DOI 10.1016/S0090-3019(03)00356-2Kobayashi M, 2002, HEPATO-GASTROENTEROL, V49, P1751Kasakura Y, 2000, SURG TODAY, V30, P485York JE, 1999, ANN SURG ONCOL, V6, P771Kim M, 1999, J NEURO-ONCOL, V43, P59KAKAR A, 1998, J ASSOC PHYSICIAN I, V46, P320Nomura T, 1997, SURG TODAY, V27, P334BONO P, 1994, PATHOLOGICA, V86, P324PATCHELL RA, 1990, NEW ENGL J MED, V322, P494OKEN MM, 1982, AM J CLIN ONCOL-CANC, V5, P649SCHWESINGER G, 1974, ZENTRALBL ALLG PATHO, V118, P473