Bone Mineral Density According to Age, Bone Age, and Pubertal Stages in Korean Children and Adolescents

To determine whether bone age (BA)-based bone mineral density (BMD) reference values are more accurate than chronological age-based BMD values in predicting the BMD of children who have a discrepancy between their chronological age and BA; we calculated BMD reference values for 514 healthy Korean children (262 girls and 252 boys) aged 5-20 yr by dual-energy X-ray absorptiometry. We found that children with BA chronological age discrepancy fitted better to the BA BMD reference curve than to the chronological age BMD reference curve. In contrast, most children without BA-chronological age discrepancy fitted well to both BA and chronological age BMD reference curves, because the 2 reference curves are very similar. In the linear regression analysis, BA-based equations for BMD had a higher R 2 value and lower standard error of estimate than chronological age-based equations. These results indicate that BA-based BMD values are more accurate in predicting BMD in children who have a discrepancy between their BA and chronological age.Gordon CM, 2008, J CLIN DENSITOM, V11, P43, DOI 10.1016/j.jocd.2007.12.005MOON JS, 2008, KOREAN J PEDIAT, V51, P1Baim S, 2008, J CLIN DENSITOM, V11, P6, DOI 10.1016/j.jocd.2007.12.002Buken B, 2007, FORENSIC SCI INT, V173, P146, DOI 10.1016/j.forsciint.2007.02.023Savaridas SL, 2007, J PEDIATR ORTHOPED, V27, P952, DOI 10.1097/bpo.0b013e31815b12f4Cui LH, 2007, J BONE MINER METAB, V25, P165, DOI 10.1007/s00774-006-0747-3Sheth RD, 2006, EPILEPSY BEHAV, V9, P601, DOI 10.1016/j.yebeh.2006.08.003Clark EM, 2006, J BONE MINER RES, V21, P1489, DOI 10.1359/JBMR.060601Ferrari SL, 2006, J BONE MINER RES, V21, P501, DOI 10.1359/JBMR.051215Cooper C, 2006, OSTEOPOROSIS INT, V17, P337, DOI 10.1007/s00198-005-2039-5Bachrach LK, 2005, ENDOCRIN METAB CLIN, V34, P521, DOI 10.1016/j.ecl.2005.04.001Pludowski P, 2005, J CLIN DENSITOM, V8, P48Jones G, 2005, BONE, V36, P352, DOI 10.1016/j.bone.2004.11.001Arabi A, 2004, BONE, V35, P1169, DOI 10.1016/j.bone.2004.06.015Freedman DS, 2002, PEDIATRICS, V110van der Sluis IM, 2002, ARCH DIS CHILD, V87, P341van der Sluis IM, 2002, J PEDIATR, V141, P204, DOI 10.1067/mpd.2002.125728Goulding A, 2001, J PEDIATR, V139, P509, DOI 10.1067/mpd.2001.116297Henderson CJ, 2000, ARTHRITIS RHEUM, V43, P531Bachrach LK, 1999, J CLIN ENDOCR METAB, V84, P4702, DOI 10.1210/jc.84.12.4702Semeao EJ, 1999, J PEDIATR, V135, P593, DOI 10.1016/S0022-3476(99)70058-2Bass S, 1999, J CLIN INVEST, V104, P795Ilich JZ, 1996, SKELETAL RADIOL, V25, P431BEUNEN GP, 1994, INT J OBESITY, V18, P542ALLEN DB, 1994, J ALLERGY CLIN IMMUN, V93, P967RECKER RR, 1992, JAMA-J AM MED ASSOC, V268, P2403KROGER H, 1992, BONE MINER, V17, P75TROUERBACH WT, 1991, BONE MINER, V13, P55GLASTRE C, 1990, J CLIN ENDOCR METAB, V70, P1330GREULICH WW, 1950, RADIOGRAPHIC ATLAS S