Detection of human rhinovirus C in children with acute lower respiratory tract infections in South Korea

Recently, HRV-C was identified as a new species of HRV, but its spectrum of clinical disease is still not clear. The purpose of this study was to investigate the molecular epidemiology of HRVs in children with acute lower respiratory tract infections (LRTIs). A total of 54 HRV-positive samples that were negative for other respiratory viruses were sequenced. HRV-A was detected in 33, HRV-B in 4, and HRV-C in 17 of these samples. All HRV-C-positive patients showed favorable clinical outcomes. We confirmed the presence of HRV-C in children with LRTIs, but its association with clinical severity is not clear.Johnstone J, 2008, CHEST, V134, P1141, DOI 10.1378/chest.08-0888Kiang D, 2008, J CLIN MICROBIOL, V46, P3736, DOI 10.1128/JCM.00674-08Khetsuriani N, 2008, EMERG INFECT DIS, V14, P1793, DOI 10.3201/eid1411.080386Briese T, 2008, EMERG INFECT DIS, V14, P944Serra MC, 2008, EUR RESPIR J, V31, P618, DOI 10.1183/09031936.00073807Renwick N, 2007, J INFECT DIS, V196, P1754, DOI 10.1086/524312Lau SKP, 2007, J CLIN MICROBIOL, V45, P3655, DOI 10.1128/JCM.01254-07Calvo C, 2007, PEDIATR INFECT DIS J, V26, P904, DOI 10.1097/INF.0b013e31812e52e6Tamura K, 2007, MOL BIOL EVOL, V24, P1596, DOI 10.1093/molbev/msm092Chung JY, 2007, J MED VIROL, V79, P1238, DOI 10.1002/jmv.20926McErlean P, 2007, J CLIN VIROL, V39, P67, DOI 10.1016/j.jcv.2007.03.012Kiang D, 2007, J CLIN VIROL, V38, P227, DOI 10.1016/j.jcv.2006.12.016TURNER RB, 2007, FIELDS VIROLOGY, P895LEE WM, 2007, PLOS ONE, V2, pE996Lamson D, 2006, J INFECT DIS, V194, P1398STANWAY G, 2005, VIRUS TAXONOMY, P757Rawlinson WD, 2003, J INFECT DIS, V187, P1314Savolainen C, 2002, VIRUS RES, V85, P41Blomqvist S, 2002, J MED VIROL, V66, P263, DOI 10.1002/jmv.2140Papadopoulos NG, 2000, J INFECT DIS, V181, P18751