Gonadotropin-releasing Hormone Receptor Expression in Endometrial Cancer

Several Studies have previously reported the expression of the gonadotropin-releasing hormone receptor (GnRHr) in cases of endometrial cancer. However, the relationship between GnRHr expression and a variety of clinicopathologic parameters remains unclear. This study was conducted with 141 endometrial cancer patients, all of whom had undergone operations between 1993 and 2002. Paraffin-embedded tissue blocks were sectioned and immunostained with monoclonal anti-GnRHr antibody. Clinicopathologic variables were also evaluated, with 10% cutoff values for GnRHr positivity. Seventy specimens (49.6%) stained as GnRHr-positive. Mean parity was higher in the patients with GnRHr-positive tumors than those with GnRHr-negative tumors (2.50 +/- 1.92 versus 1.82 +/- 1.37, P = 0.016). Body mass indices were also higher in the patients with GnRHr-positive tumors (26.6 +/- 4.6 versus 24.7 +/- 4.2, P = 0.010). However, GnRHr positivity was not determined to be statistically significantly associated with any other clinicopathologic characteristics, including age, menopausal status, histotype, disease stage, tumor differentiation, lymph node metastasis, and myometrial invasion. The results of this study, although they may require further investigation, suggested that obese and multiparous women with endometrial cancer might be greatly influenced by endogenous gonadotropin-releasing hormone and/or exogenous gonadotropin-releasing hormone analogs.This work was supported by Cancer Research Institute, Seoul National University College of Medicine (CRI-06-05).Jeon YT, 2007, ANN NY ACAD SCI, V1095, P70, DOI 10.1196/annals.1397.010Jeon YT, 2006, CANCER LETT, V239, P198, DOI 10.1016/j.canlet.2005.08.001Marelli MM, 2006, CURR CANCER DRUG TAR, V6, P257SHIOZAWA T, 2006, INT J CLIN ONCOL, V11, P13YUE Y, 2006, ZHONGHUA FU CHAN KE, V41, P326Harrison GS, 2004, ENDOCR-RELAT CANCER, V11, P725, DOI 10.1677/erc.1.00777Jeon YT, 2004, CANCER EPIDEM BIOMAR, V13, P1538Grundker C, 2002, J CLIN ENDOCR METAB, V87, P1427Volker P, 2002, AM J OBSTET GYNECOL, V186, P171, DOI 10.1067/mob.2002.119633Grundker C, 2002, EUR J ENDOCRINOL, V146, P1IMAI A, 2000, VITAM HORM, V59, P1