Intraamniotic infection with genital mycoplasmas exhibits a more intense inflammatory response than intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes

OBJECTIVE: The objective of the study was to compare the intensity of inflammatory responses between intraamniotic infection with genital mycoplasmas and intraamniotic infection with other microorganisms. STUDY DESIGN: We examined the intensity of intraamniotic and maternal inflammatory responses in 99 patients with preterm premature rupture of membranes and a positive amniotic fluid (AF) culture. AF was obtained by transabdominal amniocentesis or at the time of cesarean delivery. Patients were divided according to the recovered microorganisms: (1) genital mycoplasmas (n = 62); (2) other microorganisms (n = 31); or (3) mixed infection (n = 6). RESULTS: The median AF white blood cell (WBC) count, maternal blood WBC count, and plasma C-reactive protein concentrations were significantly higher in patients with intraamniotic infection with genital mycoplasmas than in those with intraamniotic infection with other microorganisms (P < .05 for each). CONCLUSION: Intraamniotic and maternal inflammatory responses are more intense in intraamniotic infection with genital mycoplasmas than in intraamniotic infection with other microorganisms in patients with preterm premature rupture of membranes.Novy MJ, 2009, REPROD SCI, V16, P56, DOI 10.1177/1933719108325508Jacobsson B, 2009, ACTA OBSTET GYN SCAN, V88, P63, DOI 10.1080/00016340802572646MENON R, 2009, AM J OBSTET GYNECOL, V201Viscardi RM, 2008, J PERINATOL, V28, P759, DOI 10.1038/jp.2008.98GOLDENBERG RL, 2008, AM J OBSTET GYNECOL, V198Lee HM, 2008, J HIGH ENERGY PHYSAaltonen R, 2007, BJOG-INT J OBSTET GY, V114, P1432, DOI 10.1111/j.1471-0528.2007.01410.xGotsch F, 2007, CLIN OBSTET GYNECOL, V50, P652Taylor-Robinson D, 2007, BEST PRACT RES CL OB, V21, P425, DOI 10.1016/j.bpobgyn.2007.01.011Moss TJM, 2005, AM J OBSTET GYNECOL, V192, P1179, DOI 10.1016/j.agog.2004.11.063Witt A, 2005, J PERINAT MED, V33, P22, DOI 10.1515/JPM.2005.003Berger A, 2004, J PERINAT MED, V32, P446, DOI 10.1515/JPM.2004.145Yoon BH, 2003, AM J OBSTET GYNECOL, V189, P919, DOI 10.1067/S0002-9378(03)00839-1Goncalves LF, 2002, MENT RETARD DEV D R, V8, P3, DOI 10.1002/mrdd.10008Manimtim WM, 2001, INFECT IMMUN, V69, P3906Yoon BH, 2000, AM J OBSTET GYNECOL, V183, P1130, DOI 10.1067/mob.2000.109036Yoon BH, 2000, AM J OBSTET GYNECOL, V182, P675SMULIAN JC, 1999, J MATERN FETAL MED, V8, P88Razin S, 1998, MICROBIOL MOL BIOL R, V62, P1094Yoon BH, 1998, AM J OBSTET GYNECOL, V179, P1254Gomez R, 1998, AM J OBSTET GYNECOL, V179, P194Yoon BH, 1998, OBSTET GYNECOL, V92, P77PARK KH, 1997, PRENAT NEONAT MED, V2, P294Yoon BH, 1996, OBSTET GYNECOL, V88, P1034TaylorRobinson D, 1996, CLIN INFECT DIS, V23, P671YOON BH, 1995, AM J OBSTET GYNECOL, V172, P960GRAVETT MG, 1994, AM J OBSTET GYNECOL, V171, P1660GAUTHIER DW, 1994, AM J OBSTET GYNECOL, V170, P587ROMERO R, 1993, AM J OBSTET GYNECOL, V169, P839STACEY CM, 1992, BRIT J OBSTET GYNAEC, V99, P994ROMERO R, 1992, AM J OBSTET GYNECOL, V167, P1086CAREY JC, 1991, AM J OBSTET GYNECOL, V164, P728ROMERO R, 1989, AM J OBSTET GYNECOL, V161, P817ROMERO R, 1989, OBSTET GYNECOL, V73, P532ESCHENBACH DA, 1986, PEDIATR INFECT DIS J, V5, pS258LAMEY JR, 1982, AM J OBSTET GYNECOL, V143, P104