Cyclooxygenase-2 Expression in Cervical Intraepithelial Neoplasia

To evaluate the role of cyclooxygenase (COX)-2 during cervical carcinogenesis, we investigated COX-2 expression in the dysplastic epithelium and stromal cells of cervical intraepithelial neoplasia (CIN). Immunohistochemical analysis with COX-2 antibody was performed on 148 paraffin-embedded tissue specimens of patients who were diagnosed as CIN in our institute. COX-2 expression was evaluated separately in the dysplastic epithelium and stromal cells of CIN. The relationships between COX-2 expression and clinicopathologic variables were examined. For the dysplastic epithelium, COX-2 expression was negative in 137 (92.6%) and positive in 11 (7.4%) specimens. For the stromal cells, COX-2 expression was negative in all specimens. The COX-2 expression in dysplastic epithelium was higher in older (P = 0.038) or postmenopausal (P = 0.025) women. In conclusion, COX-2 expression was observed only in the dysplastic epithelium but not in the stromal cells of CIN. The COX-2 expression in dysplastic epithelium was associated with age and menopausal status.Subbaramaiah K, 2007, CANCER RES, V67, P3976, DOI 10.1158/0008-5472.CAN-06-4273Dursun P, 2007, INT J GYNECOL CANCER, V17, P164, DOI 10.1111/j.1525-1438.2007.00798.xLee TS, 2007, ANN NY ACAD SCI, V1095, P143, DOI 10.1196/annals.1397.018Hardy DB, 2006, MOL ENDOCRINOL, V20, P2724, DOI 10.1210/me.2006-0112Kang SB, 2006, CANCER LETT, V237, P305, DOI 10.1016/j.canlet.2005.06.027Kim JY, 2005, GYNECOL ONCOL, V97, P337, DOI 10.1016/j.ygyno.2004.09.012Dai YM, 2005, GYNECOL ONCOL, V97, P96, DOI 10.1016/j.ygyno.2004.12.020Jeon YT, 2004, CANCER EPIDEM BIOMAR, V13, P1538Sheehan KM, 2004, EUR J GASTROEN HEPAT, V16, P619, DOI 10.1097/01.meg.000108313.52416.38Seo SS, 2004, GYNECOL ONCOL, V92, P927, DOI 10.1016/j.ygyno.2003.11.055Lin H, 2004, INT J GYNECOL CANCER, V14, P311Farley J, 2004, GYNECOL ONCOL, V92, P596, DOI 10.1016/j.ygyno.2003.10.052Kim MH, 2003, GYNECOL ONCOL, V90, P83, DOI 10.1016/S0090-8258(03)00224-5Kawada M, 2003, DIGESTION, V67, P20, DOI 10.1159/000069708Ferrandina G, 2002, BRIT J CANCER, V87, P1145, DOI 10.1038/sj.bjc.6600578Kim YB, 2002, CANCER, V95, P531, DOI 10.1002/cncr.10684Surh YJ, 2001, MUTAT RES-FUND MOL M, V480, P243, DOI 10.1016/S0027-5107(01)00183-XWilliams CS, 2000, J CLIN INVEST, V105, P1589Prescott SM, 2000, J CLIN INVEST, V105, P1511Williams CS, 1999, ONCOGENE, V18, P7908Tjalma W, 1999, AM J OBSTET GYNECOL, V181, P554Williams C, 1999, ANN NY ACAD SCI, V889, P72Kinzler KW, 1998, SCIENCE, V280, P1036Oshima M, 1996, CELL, V87, P803MUNGER K, 1992, CANCER SURV, V12, P197