Is there a Role of the Histologic Subtypes of Papillary Renal Cell Carcinoma as a Prognostic Factor?

Objective: The aim of this study was to compare type 1 and type 2 papillary renal cell carcinoma (RCC) for validating this subclassification as a prognostic factor. Methods: A total of 70 patients with chromophobe RCC were included in the analysis. Patients with papillary RCC were categorized into type 1 (n = 33) and type 2 (n = 37). Results: The median progression-free survival was 31.0 months for the type 1 group and 12.0 months for the type 2 group (P= 0.001). The median cancer-specific survival was 41.1 months for the type 1 group and 24.0 months for the type 2 group (P = 0.097). Multivariate Cox proportional hazards model for patients with papillary RCC showed that no variables including histologic subtyping were independent predictors of progression-free and cancer-specific survival. Conclusions: In the present study, the type of papillary RCC does not reach independent prognostic significance.Pignot G, 2007, UROLOGY, V69, P230, DOI 10.1016/j.urology.2006.09.052Sika-Paotonu D, 2006, AM J SURG PATHOL, V30, P1091Yamanaka K, 2006, INT J UROL, V13, P1049Gudbjartsson T, 2005, EUR UROL, V48, P593, DOI 10.1016/j.eururo.2005.04.016Ficarra V, 2005, CANCER, V104, P968, DOI 10.1002/cncr.21254Patard JJ, 2005, J CLIN ONCOL, V23, P2763, DOI 10.1200/JCO.2005.07.055Kim H, 2004, HUM PATHOL, V35, P1556, DOI 10.1016/j.humpath.2004.06.011Beck SDW, 2004, ANN SURG ONCOL, V11, P71, DOI 10.1245/ASO.2004.06.016Mejean A, 2003, J UROLOGY, V170, P764, DOI 10.1097/01.ju.0000081122.57148.ecCheville JC, 2003, AM J SURG PATHOL, V27, P612Allory Y, 2003, VIRCHOWS ARCH, V442, P336, DOI 10.1007/s00428-003-0787-1Leroy X, 2002, MODERN PATHOL, V15, P1126, DOI 10.1097/01.MP.0000036346.88874.25Amin MB, 2002, AM J SURG PATHOL, V26, P281SOBIN LH, 2002, TNM CLASSIFICATION MDELAHUNT B, 2002, CANCER, V94, P659Delahunt B, 2001, HUM PATHOL, V32, P590, DOI 10.1053/hupa.2001.24984Moch H, 2000, CANCER, V89, P604Ljungberg B, 1999, EUR UROL, V36, P565Jiang F, 1998, AM J PATHOL, V153, P1467Storkel S, 1997, CANCER, V80, P987Delahunt B, 1997, MODERN PATHOL, V10, P537FUHRMAN SA, 1982, AM J SURG PATHOL, V6, P655