Decreased blood flow of temporal regions of the brain in subjects with panic disorder

Lee, Yujin S
Hwang, Jaeuk
Kim, Seog Ju
Sung, Young Hoon
Kim, Jihyun
Sim, Minyoung E
Bae, Soojeong C
Kim, Minue J
Lyoo, In Kyoon

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Publication date

October 2005

DOI

10.1016/j.jpsychires.2005.08.012

Publisher

Elsevier BV

Abstract

OBJECT: The purpose of the current study was to investigate alterations of regional cerebral blood flow (rCBF) in subjects with panic disorder. METHODS: Twenty-two subjects with panic disorder who were under psychotropic medications and 25 age and gender-matched healthy comparison subjects were assessed regarding the rCBF of using Tc-99m-hexamethyl propylenamino oxime single photon emission tomography (SPECT). Using statistical parametric mapping, the rCBF was compared between panic disorder and healthy comparison groups. RESULTS: Decreased rCBF flow in right superior temporal lobe was observed in subjects with panic disorder (p<0.05 after correction for multiple comparisons). The rCBF in right superior temporal gyrus negatively correlated ...