Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are the most abundantly produced human adrenal steroids to be reduced with age. DHEA may be related to the process of skin aging through the regulation and degradation of extracelluar matrix protein. In this study, we demonstrate that DHEA can increase procollagen synthesis and inhibit collagen degradation by decreasing matrix metalloproteinases (MMP)-1 synthesis and increasing tisuue inhibitor of matrix metalloprotease (TIMP-1) production in cultured dermal fibroblasts. DHEA was found to inhibit ultraviolet (UV)-induced MMP-1 production and the UV-induced decrease of procollagen synthesis, probably due to the inhibition of UV-induced AP-1 activity. DHEA (5%) in ethanol:olive ...
Ultraviolet (UV) irradiation regulates UV-responsive genes, including matrix metalloproteinases (MMP...
Damage to human skin due to ultraviolet light from the sun (photoaging) and damage occurring as a co...
The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During the aging...
Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are the most abundantly produced hu...
Age-related impaired wound healing states lead to substantial morbidity and cost, with treatment in ...
Skin aging can be attributed to photoaging (extrinsic) and chronological (intrinsic) aging. Photoagi...
To investigate the effects of topically applied 17β-estradiol on the expression of extracellular mat...
To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular ...
Skin is the largest organ in the body comprised of three different layers including the epidermis, d...
Glucocorticoids (GCs) are one of the most effective anti-inflammatory drugs for treating acute and c...
To the best of our knowledge, no study has been conducted to date to directly compare the collagen m...
This work unveils a fish collagen drink for improvement of skin aging. Previous studies frequently d...
UV rays constitute an extremely important environmental factor known to operate adaptative mechanism...
Production of type I collagen declines during aging, leading to skin thinning and impaired function....
Background/Aims: Dehydroabietic acid (DAA) is a natural phytochemical found in red pine trees and he...
Ultraviolet (UV) irradiation regulates UV-responsive genes, including matrix metalloproteinases (MMP...
Damage to human skin due to ultraviolet light from the sun (photoaging) and damage occurring as a co...
The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During the aging...
Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are the most abundantly produced hu...
Age-related impaired wound healing states lead to substantial morbidity and cost, with treatment in ...
Skin aging can be attributed to photoaging (extrinsic) and chronological (intrinsic) aging. Photoagi...
To investigate the effects of topically applied 17β-estradiol on the expression of extracellular mat...
To investigate the effects of topically applied 17beta-estradiol on the expression of extracellular ...
Skin is the largest organ in the body comprised of three different layers including the epidermis, d...
Glucocorticoids (GCs) are one of the most effective anti-inflammatory drugs for treating acute and c...
To the best of our knowledge, no study has been conducted to date to directly compare the collagen m...
This work unveils a fish collagen drink for improvement of skin aging. Previous studies frequently d...
UV rays constitute an extremely important environmental factor known to operate adaptative mechanism...
Production of type I collagen declines during aging, leading to skin thinning and impaired function....
Background/Aims: Dehydroabietic acid (DAA) is a natural phytochemical found in red pine trees and he...
Ultraviolet (UV) irradiation regulates UV-responsive genes, including matrix metalloproteinases (MMP...
Damage to human skin due to ultraviolet light from the sun (photoaging) and damage occurring as a co...
The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During the aging...