Phenytoin의 적정복용량 결정을 위한 약력학적 분석에 관한 연구

A rapid and reliable approach in achieving an optimum individual phenytoin dosage regimen using appropriate population pharmacokinetic parameters was described. A simple graphic technique to obtain an accurate individualization of dosage regimen was also suggested. Steady state serum phenytoin concentrations were measured in 41 patients at 3 or 4 maintenance dose levels. A rapid technique for individualization of dosage adjustment was constructed using in vivo Vma x and Km values based on Michaelis-Menten kinetics. Its reliability was evaluated by comparison with other reported techniques. At dosage adjusted by the technique using steady state serum phenytoin concentration with initial maintenance dose and population Vmax based on body weight, there was highly significant correlation between observed and predicted serum concentrations(r=O.66, p