Development of new synthetic methodologies and their application towards synthesis of natural products

The thesis consists of four parts: 1. Development of methodology namely indium (III) chloride catalyzed Mukaiyama-Michael addition for the construction of 2,6-anti pyran. 2. Application of indium (III) chloride catalyzed Mukaiyama-Michael addition in the total synthesis of polyrachitide A. 3. Application of indium (III) chloride catalyzed Mukaiyama-Michael addition in the total synthesis of apicularen A. 4. Synthetic studies towards marinomycins, a potential antitumor-antibiotic macrolide isolated from the marine sponges.DOCTOR OF PHILOSOPHY (SPMS