Structural polymorphism is one of the important issue with regard to G-quadruplexes because the structural diversity may significantly affect their biological functions in vivo and also their physical properties in nano-material. A series of oligonucleotides with four repeat guanines sequences, d(G4Tn)3G4 (where n = 1-6) were designed for this study to investigate the effect of the length of loop on the polymorphism of G-quadruplex and the effect of the structure of the resulting G-quadruplex on its melting point. Via CD spectroscopy and comparison with the known CD spectrums of previously studied G-quadruplexes, and with the help of PAGE analy...
Guanine-rich DNA oligodeoxyribonucleotides (ODN) can form four-stranded structures named quadruplexe...
The development of methodology for the chemical synthesis of oligonucleotides is the first step for ...
The formation of a stable G-quadruplex (GQ) can inhibit the increased telomerase activity that is co...
A growing number of evidences suggest that DNA G-quadruplex structures play an important role in man...
G-rich DNA sequences are able to fold into structures called G-quadruplexes. To obtain general trend...
G-quadruplexes are characteristic structural arrangements of guanine-rich DNA sequences that abound ...
The central loop of G-quadruplex molecular beacons is a key element to sense target DNA or RNA seque...
Guanine-rich sequences may fold into highly ordered structures known as G-quadruplexes. Apart from t...
Background: Guanine-rich oligonucleotides are capable of forming tetrahelical structures known as G-...
To date, various G-quadruplex structures have been reported in human telomeric sequences. Human telo...
G-Rich DNA and RNA have a higher propensity to form G-quadruplex structures, but the presence of G-r...
G-rich DNA sequences have a propensity to fold into four-stranded G-quadruplex structures. As G-quad...
Guanine-rich nucleic acid sequences have a high propensity to adopt non-B DNA secondary structures l...
Oligonucleotide sequences rich in guanines are known to fold into four-stranded structures that are ...
Telomeric guanine-rich sequence can adopt quadruplex structures that are important for their biologi...
Guanine-rich DNA oligodeoxyribonucleotides (ODN) can form four-stranded structures named quadruplexe...
The development of methodology for the chemical synthesis of oligonucleotides is the first step for ...
The formation of a stable G-quadruplex (GQ) can inhibit the increased telomerase activity that is co...
A growing number of evidences suggest that DNA G-quadruplex structures play an important role in man...
G-rich DNA sequences are able to fold into structures called G-quadruplexes. To obtain general trend...
G-quadruplexes are characteristic structural arrangements of guanine-rich DNA sequences that abound ...
The central loop of G-quadruplex molecular beacons is a key element to sense target DNA or RNA seque...
Guanine-rich sequences may fold into highly ordered structures known as G-quadruplexes. Apart from t...
Background: Guanine-rich oligonucleotides are capable of forming tetrahelical structures known as G-...
To date, various G-quadruplex structures have been reported in human telomeric sequences. Human telo...
G-Rich DNA and RNA have a higher propensity to form G-quadruplex structures, but the presence of G-r...
G-rich DNA sequences have a propensity to fold into four-stranded G-quadruplex structures. As G-quad...
Guanine-rich nucleic acid sequences have a high propensity to adopt non-B DNA secondary structures l...
Oligonucleotide sequences rich in guanines are known to fold into four-stranded structures that are ...
Telomeric guanine-rich sequence can adopt quadruplex structures that are important for their biologi...
Guanine-rich DNA oligodeoxyribonucleotides (ODN) can form four-stranded structures named quadruplexe...
The development of methodology for the chemical synthesis of oligonucleotides is the first step for ...
The formation of a stable G-quadruplex (GQ) can inhibit the increased telomerase activity that is co...