Background: Dementia risk in women is higher than in men, but the molecular neuropathology of this gender difference remains poorly defined. In this study, we used unbiased, discovery-driven quantitative proteomics to assess the molecular basis of gender influences on risk of Alzheimer’s disease with cerebrovascular disease (AD + CVD). Results: We detected modulation of several redox proteins in the temporal lobe of AD + CVD subjects, and we observed sex-specific alterations in the white matter (WM) and mitochondria proteomes of female patients. Functional proteomic analysis of AD + CVD brain tissues revealed increased citrullination of arginine and deamidation of glutamine residues of myelin basic protein (MBP) in female which impaired deg...
Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, fe...
Background: Women represent the majority of Alzheimer’s disease patients and show typical symptoms. ...
Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural syndromes...
Abstract Background Alzheimer’s disease (AD) is the most common form of dementia, and it affects mor...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by altere...
Background: physiological differences between males and females could contribute to the development ...
BACKGROUND: physiological differences between males and females could contribute to the development ...
Background: physiological differences between males and females could contribute to the development ...
Many studies implicate microglia in the pathogenesis of Alzheimer's disease (AD) but precisely how t...
Dataset containing the total number of proteins significantly modulated by the effect of gender in t...
Decreased mitochondrial function is associated with aging and is an early step in Alzheimer\u27s dis...
Studies have reported higher plasma matrix metalloproteinase-9 (MMP-9) levels in mild cognitive impa...
Alzheimer's disease (AD) onset and progression is influenced by a complex interplay of several envir...
Alzheimer's disease (AD) is the most common form of dementia, with over 5. 4 million cases in the US...
White matter degeneration is a pathological hallmark of neurodegenerative diseases including Alzheim...
Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, fe...
Background: Women represent the majority of Alzheimer’s disease patients and show typical symptoms. ...
Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural syndromes...
Abstract Background Alzheimer’s disease (AD) is the most common form of dementia, and it affects mor...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by altere...
Background: physiological differences between males and females could contribute to the development ...
BACKGROUND: physiological differences between males and females could contribute to the development ...
Background: physiological differences between males and females could contribute to the development ...
Many studies implicate microglia in the pathogenesis of Alzheimer's disease (AD) but precisely how t...
Dataset containing the total number of proteins significantly modulated by the effect of gender in t...
Decreased mitochondrial function is associated with aging and is an early step in Alzheimer\u27s dis...
Studies have reported higher plasma matrix metalloproteinase-9 (MMP-9) levels in mild cognitive impa...
Alzheimer's disease (AD) onset and progression is influenced by a complex interplay of several envir...
Alzheimer's disease (AD) is the most common form of dementia, with over 5. 4 million cases in the US...
White matter degeneration is a pathological hallmark of neurodegenerative diseases including Alzheim...
Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, fe...
Background: Women represent the majority of Alzheimer’s disease patients and show typical symptoms. ...
Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural syndromes...