Background: Antimicrobial peptides (AMPs) have been shown to exhibit anticancer activity due to their unique properties. This study aims to screen a panel of hyper-charged (HC) AMPs with anti-proliferative activity and investigate the molecular mechanism in cutaneous T-cell lymphoma (CTCL), a non-Hodgkin lymphoma that is a leading cause of morbidity and mortality. Results: A panel of eight HC AMPs were screened using MTS assay against three CTCL cell lines (HuT78, MJ, HH), two DLBCL cell lines (Ly-4, Ly-18), human lung epithelial cell line A549, primary dermal fibroblasts and primary T-cells. HC-3 and HC-5 peptides showed significant anti-proliferative activity against hematolymphoid cells with IC50 ranging from 50 to 200 µg/ml. Both peptid...
Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms. Alt...
Leukemias are disorders that cause the abnormal growth and differentiation of hematopoietic cells. T...
Peptide therapeutics is a promising field for emerging anti-cancer agents. Benefits include the ease...
AbstractIn spite of great advances in cancer therapy, there is considerable current interest in deve...
Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms. Alt...
Despite great advances in cancer therapy, drug resistance is a difficult hurdle to overcome that req...
We describe a strategy to boost anticancer activity and reduce normal cell toxicity of short antimic...
Cancer which caused by the growth and spreading of abnormal cells in an uncontrolled manner remains ...
Cationic antimicrobial peptides derived from host defense peptides (HDPs), which have important role...
Cationic antimicrobial peptides derived from host defense peptides (HDPs), which have important role...
Cationic antimicrobial (host defense) peptides (CAPs) are able to kill microorganisms and cancer cel...
There is an urgent and imminent need to develop new agents to fight against cancer. In addition to t...
Cancer is one of the leading causes of morbidity and mortality globally. The drawbacks of convention...
In recent years, various research on cancer treatment has achieved significant progress. However, so...
BACKGROUND: Recent evidence suggests cathelicidin LL-37 to be a growth factor for various human canc...
Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms. Alt...
Leukemias are disorders that cause the abnormal growth and differentiation of hematopoietic cells. T...
Peptide therapeutics is a promising field for emerging anti-cancer agents. Benefits include the ease...
AbstractIn spite of great advances in cancer therapy, there is considerable current interest in deve...
Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms. Alt...
Despite great advances in cancer therapy, drug resistance is a difficult hurdle to overcome that req...
We describe a strategy to boost anticancer activity and reduce normal cell toxicity of short antimic...
Cancer which caused by the growth and spreading of abnormal cells in an uncontrolled manner remains ...
Cationic antimicrobial peptides derived from host defense peptides (HDPs), which have important role...
Cationic antimicrobial peptides derived from host defense peptides (HDPs), which have important role...
Cationic antimicrobial (host defense) peptides (CAPs) are able to kill microorganisms and cancer cel...
There is an urgent and imminent need to develop new agents to fight against cancer. In addition to t...
Cancer is one of the leading causes of morbidity and mortality globally. The drawbacks of convention...
In recent years, various research on cancer treatment has achieved significant progress. However, so...
BACKGROUND: Recent evidence suggests cathelicidin LL-37 to be a growth factor for various human canc...
Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms. Alt...
Leukemias are disorders that cause the abnormal growth and differentiation of hematopoietic cells. T...
Peptide therapeutics is a promising field for emerging anti-cancer agents. Benefits include the ease...