Engineering 3D thick porcine extracellular matrix for cardiac regeneration

This project focused on engineering a thick cardiac patch using an acellular scaffold derived from a porcine left ventricle as a possible replacement therapy for the scar tissue formed following acute heart damage. Whereas most studies demonstrated cardiac constructs with thicknesses up to a few hundred micrometers, this project aims to recellularize an acellular scaffold with comparable thickness to the human native heart (1-1.2 cm).DOCTOR OF PHILOSOPHY (MSE