Autophagy functions as a main route for the degradation of superfluous and damaged constituents of the cytoplasm. Defects in autophagy are implicated in the development of various age-dependent degenerative disorders such as cancer, neurodegeneration and tissue atrophy, and in accelerated aging. To promote basal levels of the process in pathological settings, we previously screened a small molecule library for novel autophagy-enhancing factors that inhibit the myotubularin-related phosphatase MTMR14/Jumpy, a negative regulator of autophagic membrane formation. Here we identify AUTEN-99 (autophagy enhancer-99), which activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barr...
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lyso...
Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures ...
Autophagy is a catabolic mechanism that allows cells to deliver cytoplasmic contents to lysosomes fo...
Autophagy functions as a main route for the degradation of superfluous and damaged constituents of t...
Autophagy functions as a main route for the degradation of superfluous and damaged constituents of t...
Autophagy functions as a main route for the degradation of superfluous and damaged constituents of t...
Autophagy is a major molecular mechanism that eliminates cellular damage in eukaryotic organisms. Ba...
<p>Autophagy is a major molecular mechanism that eliminates cellular damage in eukaryotic organisms....
AbstractAutophagy is an intracellular degradation process responsible for the clearance of most long...
In autophagy long-lived proteins, protein aggregates or damaged organelles are engulfed by vesicles ...
Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation....
International audienceIn autophagy long-lived proteins, protein aggregates or damaged organelles are...
Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorde...
Autophagy is the major pathway involved in the degradation of proteins and organelles, cellular remo...
Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorde...
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lyso...
Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures ...
Autophagy is a catabolic mechanism that allows cells to deliver cytoplasmic contents to lysosomes fo...
Autophagy functions as a main route for the degradation of superfluous and damaged constituents of t...
Autophagy functions as a main route for the degradation of superfluous and damaged constituents of t...
Autophagy functions as a main route for the degradation of superfluous and damaged constituents of t...
Autophagy is a major molecular mechanism that eliminates cellular damage in eukaryotic organisms. Ba...
<p>Autophagy is a major molecular mechanism that eliminates cellular damage in eukaryotic organisms....
AbstractAutophagy is an intracellular degradation process responsible for the clearance of most long...
In autophagy long-lived proteins, protein aggregates or damaged organelles are engulfed by vesicles ...
Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for degradation....
International audienceIn autophagy long-lived proteins, protein aggregates or damaged organelles are...
Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorde...
Autophagy is the major pathway involved in the degradation of proteins and organelles, cellular remo...
Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorde...
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lyso...
Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures ...
Autophagy is a catabolic mechanism that allows cells to deliver cytoplasmic contents to lysosomes fo...