Cells cultured on 2-Dimensional (2D) and 3-Dimensional (3D) substrates generally display significant differences in terms of cell shape, proliferation, morphogenesis and differentiation. While 3D substrates provide better interaction with cell-cell, cell-ECM or cell-soluble factors, tissue construct greater than 200 µm will experience involuntary cell death, e.g. necrosis within the construct. Such an involuntary cell death can be prevented by providing sufficient perfusion through the construct. The objective of this project is to develop a miniaturized 3D micro-perfused system where cells are provided with a highly relevant micro-environment by adopting the use of 3D scaffold and local perfusion. The 3D fibrous scaffold used in this st...
The field of tissue engineering aims to provide solutions for the regeneration of organs and tissues...
© 2016 The Royal Society of Chemistry. In vitro models of human tissue are crucial to our ability to...
The use of three-dimensional (3D) cell cultures has become increasingly popular in the contexts of d...
This study presents a novel approach for threedimensional (3D) cell culture using a two-component sy...
In tissue engineering, the chemical and topographical cues within three-dimensional (3D) scaffolds a...
The advent of 3D printing technologies promises to make microfluidic organ-on-chip technologies more...
One of the main challenges in drug development is the prediction of in vivo toxicity based on in vit...
Microphysiological systems (MPS), comprising human cell cultured in formats that capture features of...
Mammalian cells cultured on 2D surfaces in microfluidic channels are increasingly used in drug devel...
Breakthroughs in health care over the coming decades may well consist of cell based therapeutics, po...
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic...
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic...
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic...
Organ loss and failure is one of the most critical issues facing the healthcare industry in develope...
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic...
The field of tissue engineering aims to provide solutions for the regeneration of organs and tissues...
© 2016 The Royal Society of Chemistry. In vitro models of human tissue are crucial to our ability to...
The use of three-dimensional (3D) cell cultures has become increasingly popular in the contexts of d...
This study presents a novel approach for threedimensional (3D) cell culture using a two-component sy...
In tissue engineering, the chemical and topographical cues within three-dimensional (3D) scaffolds a...
The advent of 3D printing technologies promises to make microfluidic organ-on-chip technologies more...
One of the main challenges in drug development is the prediction of in vivo toxicity based on in vit...
Microphysiological systems (MPS), comprising human cell cultured in formats that capture features of...
Mammalian cells cultured on 2D surfaces in microfluidic channels are increasingly used in drug devel...
Breakthroughs in health care over the coming decades may well consist of cell based therapeutics, po...
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic...
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic...
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic...
Organ loss and failure is one of the most critical issues facing the healthcare industry in develope...
Faithful modeling of tissues and organs requires the development of systems reflecting their dynamic...
The field of tissue engineering aims to provide solutions for the regeneration of organs and tissues...
© 2016 The Royal Society of Chemistry. In vitro models of human tissue are crucial to our ability to...
The use of three-dimensional (3D) cell cultures has become increasingly popular in the contexts of d...