Add to ORKGAngelman syndrome (AS) is a neurological disorder which is caused by loss of maternally expressed genes on the human chromosome 15q11-q13 in the brain. AS patients show signs of mental retardation, seizures, lack of speech and ataxic gait. In this study, we would like to look into Ube3a, whose mutation or deletion caused AS, by performing Ube3a knockdown in P19 cell line and heat shock assay in cells. Ube3a knockdown cells showed reduction in both transcription and translation levels of the encoded protein, E6-AP. Increase in HSP70 mRNA levels was also observed in knockdown cells. Under heat stress condition, E6-AP was not found to be induced, unlike HSP70 whose expression increase dramatically. RNA obtained from knockdown cells will be use...
Angelman syndrome (AS) is an inheritable neurodevelopmental disorder resulting from the loss of func...
Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is...
Angelman syndrome (AS) is an inheritable neurodevelopmental disorder resulting from the loss of func...
Angelman syndrome (AS) is a neurological disorder which is caused by loss of maternally expressed ge...
Failure to inherit a normal active maternal copy of the gene encoding ubiquitin protein ligase E3A (...
Failure to inherit a normal active maternal copy of the gene encoding ubiquitin protein ligase E3A (...
Failure to inherit a normal active maternal copy of the gene encoding ubiquitin protein ligase E3A (...
the neuroscience of UBE3A. Angelman syndrome is characterized by loss of speech, severe developmenta...
Angelman syndrome (AS) is a human developmental disorder that presents with ataxia, seizures, and ma...
Angelman Syndrome (AS) is a neurodevelopment disorder for which there is currently no cure that is c...
Angelman Syndrome (AS) is a neurodevelopment disorder for which there is currently no cure that is c...
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutation or deletion of the...
Angelman syndrome (AS) is a human neurological disorder caused by lack of maternal UBE3A expression ...
Angelman syndrome (AS) is a rare genetic disorder characterized by severe intellectual disability, s...
Angelman syndrome is a neurobehavioral disease associated with the loss of maternally expressed E3 u...
Angelman syndrome (AS) is an inheritable neurodevelopmental disorder resulting from the loss of func...
Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is...
Angelman syndrome (AS) is an inheritable neurodevelopmental disorder resulting from the loss of func...
Angelman syndrome (AS) is a neurological disorder which is caused by loss of maternally expressed ge...
Failure to inherit a normal active maternal copy of the gene encoding ubiquitin protein ligase E3A (...
Failure to inherit a normal active maternal copy of the gene encoding ubiquitin protein ligase E3A (...
Failure to inherit a normal active maternal copy of the gene encoding ubiquitin protein ligase E3A (...
the neuroscience of UBE3A. Angelman syndrome is characterized by loss of speech, severe developmenta...
Angelman syndrome (AS) is a human developmental disorder that presents with ataxia, seizures, and ma...
Angelman Syndrome (AS) is a neurodevelopment disorder for which there is currently no cure that is c...
Angelman Syndrome (AS) is a neurodevelopment disorder for which there is currently no cure that is c...
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutation or deletion of the...
Angelman syndrome (AS) is a human neurological disorder caused by lack of maternal UBE3A expression ...
Angelman syndrome (AS) is a rare genetic disorder characterized by severe intellectual disability, s...
Angelman syndrome is a neurobehavioral disease associated with the loss of maternally expressed E3 u...
Angelman syndrome (AS) is an inheritable neurodevelopmental disorder resulting from the loss of func...
Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is...
Angelman syndrome (AS) is an inheritable neurodevelopmental disorder resulting from the loss of func...