International audienceBackground: Recommendations for pharmacological treatments of major depression with specific comorbid psychiatric conditions are lacking. Method: The French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental developed expert consensus guidelines for the management of depression based on the RAND/ UCLA Appropriatneness Method. Recommendations for lines of treatment are provided by the scientific committee after data analysis and interpretation of the results of a survey of 36 psychiatrist experts in the field of major depression and its treatments. Results: The expert guidelines combine scientific evidence and expert clinician's opinion to produce recommendations for major de...