Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles

  • Iglesias, G. R.
  • Reyes-Ortega, Felisa
  • Checa Fernandez, B. L.
  • Delgado, Ángel V.
Publication date
March 2018
Publisher
MDPI
Journal
issn:2073-4360

Abstract

In this work a combined, multifunctional platform, which was devised for the simultaneous application of magnetic hyperthermia and the delivery of the antitumor drug gemcitabine, is described and tested in vitro. The system consists of magnetite particles embedded in a polymer envelope, designed to make them biocompatible, thanks to the presence of poly (ethylene glycol) in the polymer shell. The commercial particles, after thorough cleaning, are provided with carboxyl terminal groups, so that at physiological pH they present negative surface charge. This was proved by electrophoresis, and makes it possible to electrostatically adsorb gemcitabine hydrochloride, which is the active drug of the resulting nanostructure. Both electrophor...

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