Add to ORKGThe reaction of cis-[Pt(15NH3)2(H2O)2]2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3)2(SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3)2(SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3)2(SG)2] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts. Keywords: 15N NMR, glutathione, cisplatin hydrolyte
15N and 195Pt NMR spectra have shown that [Pt( 15NH 3) 3] 2(μ-OH) 3+ slowly forms when a solution co...
Cisplatin is an important anti-cancer drug. Structurally, cisplatin is a coordination complex, which...
Thesis (Ph. D.)--University of Hawaii at Manoa, 1995.Includes bibliographical references (leaves 121...
The reaction of cis-[Pt(NH)(H O)] (3) with N-acetylcysteine [H accys] was investigated in aqueous so...
The interactions of cis-[PtCl(NH) (HO)](NO) (2) with L-cysteine (H cys) was investigated in aqueous ...
The reactions of cis-[PtCl(NH3)2(H2O)]+ with l-methionine have been studied by 1D 195Pt and 15N NMR,...
The reactions of cis-[PtCl(NH3)(2)(H2O)](+) with L-methionine have been studied by 1D Pt-195 and N-1...
A study of the reaction between trans-[Pt(15NH3)2(H2O)2](NO3)2 and glutathione (GSH) was undertaken ...
195Pt, 15N, 1H, and 13C NMR spectra have been used to study the reactions between cis-Pt(NH 3) 2(H 2...
A study of the reaction between trans-[Pt(15NH3)2(H2O)2](NO3)2 and N-acetyl-L-cysteine (H3accys) was...
International audienceInteraction of platinum-based drugs with proteins containing sulphur amino aci...
The reactions of cis-Pt(NH)(HO) with S-methyl-L-cysteine (mecysH) and L-methionine (metH) have been ...
[[abstract]]The Pt–S bond of Pt(II)–glutathione (GS–Pt) complex was dissociable in neutral phosphate...
The binding of platinum (Pt) drugs (oxaliplatin, carboplatin, and cisplatin) to glutathione (GSH, 6....
The reactions of cisplatin [cis-diamminedichloroplatinum(II), CDDP] with glutathione (GSH) and drug ...
15N and 195Pt NMR spectra have shown that [Pt( 15NH 3) 3] 2(μ-OH) 3+ slowly forms when a solution co...
Cisplatin is an important anti-cancer drug. Structurally, cisplatin is a coordination complex, which...
Thesis (Ph. D.)--University of Hawaii at Manoa, 1995.Includes bibliographical references (leaves 121...
The reaction of cis-[Pt(NH)(H O)] (3) with N-acetylcysteine [H accys] was investigated in aqueous so...
The interactions of cis-[PtCl(NH) (HO)](NO) (2) with L-cysteine (H cys) was investigated in aqueous ...
The reactions of cis-[PtCl(NH3)2(H2O)]+ with l-methionine have been studied by 1D 195Pt and 15N NMR,...
The reactions of cis-[PtCl(NH3)(2)(H2O)](+) with L-methionine have been studied by 1D Pt-195 and N-1...
A study of the reaction between trans-[Pt(15NH3)2(H2O)2](NO3)2 and glutathione (GSH) was undertaken ...
195Pt, 15N, 1H, and 13C NMR spectra have been used to study the reactions between cis-Pt(NH 3) 2(H 2...
A study of the reaction between trans-[Pt(15NH3)2(H2O)2](NO3)2 and N-acetyl-L-cysteine (H3accys) was...
International audienceInteraction of platinum-based drugs with proteins containing sulphur amino aci...
The reactions of cis-Pt(NH)(HO) with S-methyl-L-cysteine (mecysH) and L-methionine (metH) have been ...
[[abstract]]The Pt–S bond of Pt(II)–glutathione (GS–Pt) complex was dissociable in neutral phosphate...
The binding of platinum (Pt) drugs (oxaliplatin, carboplatin, and cisplatin) to glutathione (GSH, 6....
The reactions of cisplatin [cis-diamminedichloroplatinum(II), CDDP] with glutathione (GSH) and drug ...
15N and 195Pt NMR spectra have shown that [Pt( 15NH 3) 3] 2(μ-OH) 3+ slowly forms when a solution co...
Cisplatin is an important anti-cancer drug. Structurally, cisplatin is a coordination complex, which...
Thesis (Ph. D.)--University of Hawaii at Manoa, 1995.Includes bibliographical references (leaves 121...