Effect Of Hydrogel Dressing Copolymer Poli(Vinylpirrolidone) (Pvp) - K- Carrageenan Prepared By Radiation And Healing Times On The Radius Reductions Burn Injuried Of Wist Ar White Rat = Pembalut Hldrogel Kopollmer....

ABSTRACT The pre-clinical study of poly (vinyl pirrolidone) (PVP)-K- carrageenan hydrogel has been carried out. The aim of this study is to investigate the effect of hydrogel for healing bum injuried in the rats. The hydrogels wenJ prepared by r-irradiation of aqueous solutions of 15 wt.-% PVP and 2 wt.-% K- carrageenan at a sterilization dose of 25 kGy. The physico-chemical properties of hydrogels were investigated.. The results showed that the hydrogels suitable as candidate for wound dressing with gel fraction of 90:t 5 (%), the water absorption was 4500 :r 55 (WIW), the water content was 83 :t 2 (0"\u27), tensile .strength was 1,5 :t 0, 1 kg/cm2 and adhesiveness was O. The effect of the hydrogel as wound dressing was evaluated by attaching to a bum of the back skin of rats as a function of time observation. Advantages of the hydrogel were slightly faster rate of reducing radius diameter of injured bum skin, easy removal without damage to renewed skin. Keywords: hydrogel, irradiation, copolymer, PVP, 1( carrageenan