Recurrence and distant free survival: study on breast cancer prognostic factor in Yogyakarta

ABSTRAK Recurrence and Distant free Survival : Study on Breast Cancer Prognostic Factor in Yogyakarta. Background : Relapse and distant metastasis in breast cancer depends on several factor such as clinical, morphological and biological prognostic factors. Objective: The aim of this study was to know prognostic factors of operable breast cancer patients in Yogyakarta, and its relation with recurrence and distant free survival. Methods : Prospective design was applied duct invasive operable breast cancer patients who had been diagnosed and treated since 1993 were followed prospectively for clinical, pathological stage, age, tumor size, lymph node status, histological grade, mitotic index, ER,PR, c-erbB2, p53 and MIB-1, until revealed outcome (recurrence and distant metastasis). Prognostic factor was analyzed univariately for recurrence and distant metastasis with Kaplan Meier method. Difference between two survival group was analyzed with log- rank test. Independent prognostic factor was analyzed multivariately using proportional hazard (Cox) regression. Results: Significant prognostic factor for recurrence was c-erbB2 expression (p=0.0341. Univariate analysis showed that significant prognostic factors for distant metastasis were pathological stage, lymph node status, age and c-erbB2 expression. With multivariate analysis, most significant prognostic factors for distant metastasis were lymph node status (p=0.0151 and age (p=0.042). Conclusion: Independent prognostic factors for recurrence were c-erbB2 expression, while for distant metastasis were lymph node status and age. Key Words : breast cancer, prognostic factor, recurrence free survival, distant free survival-c-erbB