Add to ORKGBloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BLM that is associated with growth retardation and predisposition to cancer. BLM helicase has a high specificity for non-canonical G-quadruplex (G4) DNA structures, which are formed by G-rich DNA strands and play an important role in the maintenance of genomic integrity. Here we used single-molecule FRET to define the mechanism of interaction of BLM helicase with intra-stranded G4 structures. We show that the activity of BLM is substrate dependent, and highly regulated by a short-strand DNA (ssDNA) segment that separates the G4 motif from double-stranded DNA. We demonstrate cooperativity between the RQC and HRDC domains of BLM during binding an...
Bloom syndrome is a cancer predisposition disorder caused by mutations in the BLM helicase gene. Cel...
To understand the speci®c genetic instabilities associated with de®ciencies in RecQ family heli-case...
International audienceAbstract Bloom's syndrome (BLM) protein is a known nuclear helicase that is ab...
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BL...
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BL...
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BL...
Mutations in the RecQ DNA helicase gene BLM give rise to Bloom’s syndrome, which is a rare autosomal...
Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which play key role...
Various helicases and single stranded DNA (ss-DNA) binding proteins unfold G-quadruplex (GQ) structu...
Bloom helicase (BLM) is a member of the RecQ helicase family, a group of 3’ to 5’ helicases which ar...
Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadru...
The product of the gene mutated in Bloom's syndrome, BLM, is a 3′-5′ DNA helicase belonging to the h...
The RecQ family DNA helicases WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) play a ...
The RecQ family of helicases are important for maintenance of genomic integrity. Although functions ...
RECQ5 is one of five members of the RecQ family of helicases in humans, which include RECQ1, Bloom (...
Bloom syndrome is a cancer predisposition disorder caused by mutations in the BLM helicase gene. Cel...
To understand the speci®c genetic instabilities associated with de®ciencies in RecQ family heli-case...
International audienceAbstract Bloom's syndrome (BLM) protein is a known nuclear helicase that is ab...
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BL...
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BL...
Bloom syndrome is an autosomal recessive disorder caused by mutations in the RecQ family helicase BL...
Mutations in the RecQ DNA helicase gene BLM give rise to Bloom’s syndrome, which is a rare autosomal...
Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which play key role...
Various helicases and single stranded DNA (ss-DNA) binding proteins unfold G-quadruplex (GQ) structu...
Bloom helicase (BLM) is a member of the RecQ helicase family, a group of 3’ to 5’ helicases which ar...
Various helicases and single-stranded DNA (ssDNA) binding proteins are known to destabilize G-quadru...
The product of the gene mutated in Bloom's syndrome, BLM, is a 3′-5′ DNA helicase belonging to the h...
The RecQ family DNA helicases WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) play a ...
The RecQ family of helicases are important for maintenance of genomic integrity. Although functions ...
RECQ5 is one of five members of the RecQ family of helicases in humans, which include RECQ1, Bloom (...
Bloom syndrome is a cancer predisposition disorder caused by mutations in the BLM helicase gene. Cel...
To understand the speci®c genetic instabilities associated with de®ciencies in RecQ family heli-case...
International audienceAbstract Bloom's syndrome (BLM) protein is a known nuclear helicase that is ab...